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2000
Volume 22, Issue 2
  • ISSN: 1871-5257
  • E-ISSN: 1875-6182

Abstract

Aims

The study aimed to investigate the antihypertensive activity of ssp.

Background

ssp locally known as “”, is used in traditional medicine in Morocco as a diuretic and mainly against snake bites.

Objectives

This study investigated the possible antihypertensive effect of the aqueous extract of (AESU).

Materials and Methods

In the present study, the antihypertensive activity of AESU was tested in normotensive and hypertensive rats.

Results

The results indicated that AESU decreased the systolic, diastolic, and mean arterial blood pressure in hypertensive rats. The data revealed that AESU exerted its antihypertensive effect through vasodilatory properties. Interestingly, the study demonstrated that the vasorelaxation ability of AESU might be mediated through receptor-operated calcium channels (ROCCs). However, AESU dhad effect on inhibiting ACE-2.

Conclusion

The present study indicates the antihypertensive and vasorelaxant activities of AESU in hypertensive rats.

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2024-06-01
2024-11-23
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