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s Mild and Green Protocol for Selective Deuteration of Quercetin-3-O-Rutinoside (Rutin) Under Aqueous Basic Conditions
- Source: Current Green Chemistry, Volume 6, Issue 2, Aug 2019, p. 147 - 151
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- 01 Aug 2019
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Abstract
A convenient and cost-effective method for selective deuteration of rutin using biologically compatible bases and D2O both as a deuterium source and a solvent is herein reported. The protocol is benign and inexpensive affording good results in very mild conditions allowing to reduce the required amount of deuterium oxide. The position of the C-H/C-D exchange and the level of deuteration can be conveniently followed by 1H-NMR.
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