Current Genomics - Volume 4, Issue 6, 2003

Hsp70 molecular chaperones play a variety of functions in every organism, cell type and compartment, and their activities have been implicated in a number of disease states. Hsp70 activity relies on ATP binding and hydrolysis by the N-terminal domain, which modulates peptide binding and release by the C-terminal domain. In Escherichia coli, the Hsp70 family member DnaK is regulated by DnaJ, which stimulates its ATPase Read More

Learning and memory is a property of central importance in the nervous system, yet many of the molecular mechanisms for this behavior remain enshrouded in mystery. Despite the daunting nature of the problem, a number of complementary strategies have been employed to unravel the complexities of learning and memory, ranging from genetics to biochemistry. One of the most recent tools brought to bear in this area i Read More

The decipherment of the human and yeast as well as numerous pathogen genomes has resulted in an explosion of DNA sequence data. Additionally, a plethora of expressed sequences from various tissues and cells are available that cover much more than the estimated actual number of genes within a eukaryotic genome. Although the homology between the mammalian chromosomes, genomes and genes is w Read More

The leukocyte integrins are essential membrane receptors that mediate leukocyte adhesion to various cells during immune and inflammatory responses including tumor cell killing, leukocyte migration from the bloodstream into inflamed tissues, and phagocytosis of bacteria. The importance of these receptors is underscored in humans with leukocyte adhesion deficiency (LAD), that is caused by the absence or gre Read More

During the last few years, high throughput RNA profiling technologies have become nearly indispensable tools in biomedical research. Optimization strategies for the different technologies and bioinformatics tools to mine the wealth of data have developed rapidly to meet the researcher's need calling for more sophisticated clinical and pharmaceutical applications and a more integrated view of the cell's primary molecules DNA, Read More