Current Genomics - Volume 4, Issue 5, 2003

Hereditary hearing impairment (HHI) is a heterogeneous class of disorders showing various patterns of inheritance and involving a multitude of different genes. Neurosensory hearing impairment is one of the most common human sensory disorders affecting one in 1000 children with at least 60% of cases being inherited. The mode of inheritance of non-syndromic hearing disorders can be assigned to autosomal dominant (10- Read More

Transitional cell carcinomas of the urinary bladder are frequently characterised by multiple local recurrences with a low risk of progression. The observation that a significant proportion of patients experience recurrences over many years, even decades, without ever developing aggressive life threatening disease has led to the hypothesis that recurrence is a separate clinical and molecular event in the natural history of this Read More

Ageing-dependent dysfunctions develop for each of various cell types in living organisms. Amongst them, immunosenescence, an ageing-dependent deterioration of the immune system, seriously affects the health condition of an aged individual. The central problem in immunosenescence is a decrease in the ability of T-cells to respond to antigens for proliferation and cytokine production, accompanied Read More

The analysis of gene expression has been revolutionized over recent years through the use of DNA arrays that can monitor the expression of thousands of genes. The field has great potential but requires a multidisciplinary approach integrating biochemistry with computer science, statistics, and engineering. Analysis of gene expression data has no golden rule, and the methodologies vary extensively between studie Read More