Current Enzyme Inhibition - Volume 14, Issue 1, 2018

Chalcones and aurones are natural products which belong to the flavonoid family and possess a variety of pharmacological and biological activities. Chalcones and, in a lesser extent, aurones, are especially versatile chemical scaffolds, therefore a large number of synthetic analogues have been prepared and studied for their tyrosinase inhibitory activity. This report aims to briefly present all the studies about the tyrosinase inhibit Read More

Introduction: Modified quinolines have been used as metal chelators, and they have drawn the attention of researchers due to the possible biological approaches with a broad scope of application. This study aims to evaluate the in vitro biological effects of seven quinolinic compounds in RAW macrophage culture, blood cells and in Candida albicans fungus. Methods: Cell viability and proliferation of macrophages were eval Read More

Background: A range of biological activities including anti-inflammatory, antiangiogenic, antitubercular and kinase inhibitory activity have been reported for pyrazole derivatives. Serious medicinal chemistry approaches for the development of effective antibacterial agents have resulted in only few new compounds with the lack of activity against a wide range of microbes. In continuation with our quest for developing anti-inf Read More

Background: The involvement of 3α-hydroxysteroid dehydrogenase (3α-HSD AKR1C2) in the processes of liver metastasis and prostate cancer has been previously reported. Increased 5α- reductase 1 (5α-R1) activity in prostate cancer has also been reported. Therefore, overexpression of 3α-HSD and 5α-R1 could be related to drug resistance and disease progression of liver and prostate tumors. Aim: The aim of this study was Read More

Background: Depression associated with asthma enhances asthma-related morbidity and mortality. While antidepressants (AD) are prescribed in depression, β2-adrenergic agonists (BAA) and xanthines are used in asthma. Asthma treatment side effects include depression and suicidal ideation. Objective: Here, we identified a possible mechanism of BAA and xanthines to induce depressant or antidepressant responses b Read More

Background: Nowadays molecular modeling is widely used in different areas of scientific research. Especially in medical and pharmaceutical research molecular modeling allows saving time and money in conception of new drugs by comprehension of interaction between disease's enzymes and inhibitors for probable formation of stable complex. Cinnamon as famous plant and culinary spice is highly recommended i Read More

Background: Many peptides are produced from food proteins during the manufacturing of various functional foods; unexpected and valuable physiological activities are frequently identified in such released peptides. Elastin, which normally exists as an insoluble elastic fiber, is being used as a new health food material in accordance with the progress in solubilization techniques for elastin. Objective: To evaluate the usefulness Read More

Background: Trypsin Inhibitors are one of the most promising and investigated subject for their role in pharmacognostical and pharmacological studies. Aim: The paper describes purification and characterization of trypsin inhibitor obtained from blackeyed cowpea (Vigna unguiculata). Methods: The purification procedure of Vigna unguiculata trypsin inhibitor (VUTI) includes homogenization followed by ammonium sulph Read More