Current Drug Therapy - Volume 8, Issue 3, 2013

Benzimidazole derivatives play an important role in medical field with so many Pharmacological activities, such as selective neuropeptides YY1 receptor antagonists, gamma-amino butyric acid (GABA) agonists, and 5-HT3 antagonists, anticonvulsant and other activities encouraged the development of some more potent and significant compounds. This review presents different substituted benzimidazole derivatives whic Read More

Aim: The objective was to assess the effect of inhaled doses of GW870086, a novel selective corticosteroid, on allergen-induced early and late asthmatic responses (EAR/LAR). Methods: Twenty-four males with mild asthma were randomised in a double-blind, three-way crossover study to receive GW870086 0.25 mg, 1 mg and 3 mg once-daily, fluticasone propionate (FP) 0.25 mg twice-daily or placebo for 13 days. Results: Read More

Both osteoporosis and hypertension are major diseases in aging populations. This work was provided to investigate the possible effect of the nonselective beta adrenoceptor antagonist; carvedilol against postmenopausal osteoporosis in adult rats. Ovariectomized rats were gavaged with carvedilol (10 mg/kg) daily for 60 days. Serum levels of estradiol, calcium and osteoblastic markers (alkaline phosphatase and osteocalci Read More

Since 1972, I have been treating children with amphetamines and somewhat later with methylphenidate (Ritalin) for Minimal Brain Damage, a diagnostic term used in those early years for children with Attention Deficit Hyperactivity Disorder (ADHD). Similar to other colleagues, I have also noted a continuous rise in the interest, understanding, and rate of diagnosis and drug treatment given to children, adolescents and adult Read More

Transdermal route is preferred due to its numerous advantages over other routes. Stratum corneum and other skin layers are the foremost obstacles in employing skin as a drug delivery route. So various penetration enhancement techniques are utilized which cause the delivery of drug through the skin in proper amounts and at a predetermined rate. Permeation enhancers are the agents which do not have any therapeu Read More

The treatment of many diseases owes much to the important medicines that have been derived from plants, cancer is no exception. Cancer is a class of diseases characterized by out-of-control cell growth. Researchers have developed many agents which have shown brilliant therapeutic results against cancerous cells out of which the microtubule-targeting agents (MTAs) have made significant contributions to cancer ther Read More

Human echinococcosis or hydatid disease still causes serious health problems with a worldwide geographical distribution. This parasitic infection is a chronic, complex, and still neglected disease. Currently four treatment modalities are in use: surgery, PAIR (puncture, aspiration, injection of protoscolicidal agent, reaspiration), chemotherapy and a “watch and wait” approach for inactive, clinically silent cysts. Over the past 30 Read More

Aims: The purpose of this research is to develop a novel expandable gastroretentive dosage form (GRDF), based on an unfolding mechanism. It consists of a drug loaded bilayer polymeric film, folded into a hard gelatin capsule. Gastric retention is achieved due to unfolding of the dosage form within 15-20 min. Captopril is selected as the drug candidate for this work. Due to its narrow absorption window, Captopril has to b Read More