Current Drug Therapy - Volume 8, Issue 1, 2013

Benzimidazoles exhibit a broad range of biological activities. Several benzimidazoles are used in therapy such as albendazole, mebendazole, flubendazole, fenbendazole, omeprazole, lansoprazole,clofazimine. Benzimidazole derivatives play a vital role in the biological field such as antimicrobial, antiviral, antidiabetic, antiulcer and anticancer activities. The present review highlights the recently synthesized benzimida Read More

Cancer is a worldwide leading cause of death. Multiple genetic mutations or environmental influences lead to the change of cellular functions that result in malignant transformation. Therapeutic approaches, such as surgery, chemotherapy and radiotherapy have harmful side effects due to their inability to specifically target particular tumors. Each therapeutic strategy is aimed to affect the target tumor cells with minimum t Read More

More than 90% of cancer deaths are caused by cancer metastasis. Since cancer metastasis is the main cause of human deaths, so in this article more attention will be paid to it than ever before. Presently, clinical cancer chemotherapies have been targeting on primary tumors rather than on metastatic processes. Since the antimetastatic drugs are different from antiproliferative drugs and underinvestigated, cancer patients’ s Read More

Background: Early treatment for infertile women with polycystic ovary syndrome (PCOS) is likely crucial and includes mainly clomiphene citrate (CC) and metformin. Objectives: To review the literature data regarding the use of CC, metformin, or both for the treatment of infertility in anovulatory patients with PCOS. Materials and Methods: Using PubMed database, all main relevant articles studying therapy naive patients with PCO Read More

In July 2007, all peritoneal dialysis (PD) patients in our hospital were switched from mupirocin to gentamicin ointment for daily application to the PD catheter exit site (CES). Our objective was to compare the efficacy of gentamicin and mupirocin in the prevention of catheter-related PD infections. We conducted an observational sequential cohort study to compare infectious outcomes with the 2 ointments. Mupirocin patients were f Read More

Psoriasis is a chronic, often difficult to control condition which accounts for significant morbidity worldwide. The United States Food and Drug Administration (FDA) approved multiple TNF alpha blockers in the 21st century for the treatment of psoriasis. These agents provide an alternative treatment approach for those with moderate to severe psoriasis, who fail to respond adequately to traditional therapies. The increasing Read More

Microbicides as a potential intervention strategy for preventing human immunodeficiency virus (HIV) transmission, provide women with a preventive option against HIV. For more than two decades, various studies have endeavored to find effective and safe microbicides, which would provide defense against HIV/AIDS. Microbicides include various agents having different mechanisms such as, disruption of cellular and m Read More