Current Drug Therapy - Volume 18, Issue 3, 2023

Background: As the COVID era unfolds, researchers reveal that rapid changes in viral genetic material allow viruses to circumvent challenges triggered by the host immune system and resist anti-viral drugs, potentially leading to persistent viral manifestations in host cells. Molnupiravir (RNA-dependent RNA polymerase inhibitor) is a novel anti-viral medicine promising a vital role in coming setbacks. Objectives: This revie Read More

Background: Nanotechnology is moving toward future goals in the field of medicines, cosmetics and hospitality due to the size reduction of material in the range of 1-100nm, enhancing the stability and bioavailability of the material. Objective: This review includes the progress in the field of nanotechnology, its advantages, understanding and applications in antimicrobial therapy. Methods: The manuscripts were collected in th Read More

Introduction: Yellow fever is an infectious disease endemic to Africa, and Central and South America with a significant impact on public health, causing outbreaks and epidemics. Clinical manifestations can vary from asymptomatic to more severe and lethal disease outcomes. The primary prevention of yellow fever occurs through the vaccination of individuals, which confers immunity for life. Patients with chronic kidney dis Read More

Background: Since patients admitted to the intensive care unit have a compromised immune system and are more prone to infection than other patients, timely diagnosis and treatment of corneal ulcers among this group of patients can prevent vision loss. Therefore, it is necessary to treat eye infections and corneal ulcers promptly and economize prohibitive costs. Objective: Appropriate treatment with the most effective an Read More

Background: The present work describes the systematic development and optimization of cyclosporine-A loaded biodegradable polymeric nanoparticulate system using quality by design paradigm, to achieve an effective and sustained release of the cyclosporine-A to the targeted lesion of plaque psoriasis. Methods: The polymeric nanoparticles were formulated using the solvent emulsification method using Polycaprolact Read More

Background: Methotrexate is a cytotoxic chemotherapeutic agent that has severe side effects, such as nephrotoxicity. Momordica charantia is a bright yellow-orange fruity plant that has been shown to have antioxidant, antidiabetic, and anti-inflammatory properties. Objective: This study scrutinized the protective effects of Momordica charantia extract against methotrexate- induced nephrotoxicity. Methods: 24 Sprague D Read More

Background: This study aims to develop a new hepatoprotective drug from common plants and vitamins that are potent, nontoxic, and cost-effective. The literature search found that Curcuma longa , Zingiber officinale, Terminalia, chebula, and Vitamin A (Vitamin C + Vitamin E) provide hepatoprotective action against drugs-induced hepatotoxicity. A major side effect of antitubercular drugs (ATD) is liver toxicity, which re Read More

Background: Cancer is a leading cause of death for people worldwide, in addition to the rise in mortality rates attributed to the Covid epidemic. This allows scientists to do additional research. Here, we have selected Integerrimide A, cordy heptapeptide, and Oligotetrapeptide as the three cyclic proteins that will be further studied and investigated in this context. Methods: Docking research was carried out using the protein compl Read More

Background: Untreated cardiovascular disease (CVD) can commonly cause disability and morbidity and increase the mortality risk. Objective: This systematic review and meta-analysis study aimed to investigate the pain-relieving effects of aromatherapy with medicinal plants on patients with cardiovascular diseases. Methods: This meta-analysis followed PRISMA guidelines. Several keywords were explored using an extensive s Read More