Current Drug Therapy - Volume 15, Issue 5, 2020

Coronavirus (CoV) is an enveloped positive-sense RNA virus. Coronavirus disease 2019 (COVID-19) is an acute respiratory disease, induced by a new type of coronavirus, SARS-CoV-2. COVID-19 has originated in China and spread quickly all over the world. WHO acknowledged the outbreak of a global pandemic on March 11, 2020. The spread of COVID-19 signified a big threat to social life, the economy, and public health. As of Read More

Background: Different experimental methods have been used to induce diabetes in animals. There are a number of anti-diabetic drug loaded nano-formulations with high therapeutic value that are used to target diabetes with high therapeutic efficacy. Methods: From this review, various anti-hyperglycemic agents have been screened for their activity. The use of nano-formulation in diabetes treatment is considered due to the Read More

Background: Coronaviruses (CoVs), having enveloped RNA of positive strand, are mainly responsible for enzootic infections in mammals. The mortality of CoVs has been proved as they can cross the species barrier very easily and infect humans. Most recently, the outbreak of coronavirus induced COVID-19 emerged in the city of Wuhan, Hubei province of China and became the third highly pathogenic coronavirus infecting Read More

Nanoparticles (Np) are the 21st century material in supreme formulations due to their unique properties and design. In review, systematic discussion of the synthesis, characterization, bio-applications, and risks of AgNps (Silver Nanoparticles) especially highlighting anticancer activity envisaging mechanisms as well as therapeutic approaches for cancer. Ag-Nps mainly possess toxicological concern. Benefits and Risk: A Read More

Introduction: The infiltration of HIV into the brain alters the functions of the nervous system known as Neuro-AIDS. It leads to neuronal defects clinically manifested by motor and cognitive dysfunctions. Materials and Methods: Current antiretroviral therapy can prevent viral replication but cannot cure the disease completely. HAART-Highly active antiretroviral therapy is used for the treatment of HIV infection. Challenges in Read More

Background: The Microcrystalline Cellulose is called as a gold standard for the manufacture of pellets. The poor disintegration leads to incomplete drug release that restricts the use of MCC in the immediate-release formulation. Objective: The present work aims to explore non-MCC extruder aid for pellet formulation and solubility modulation potential of Aeroperl® 300 Pharma. Methods: Bicalutamide (BCL) was selected as a mod Read More

Objective: Carbonyl stress, resulting from toxic effects of alpha-dicarbonyls such as glyoxal (GO), plays an important role in mitochondrial dysfunction and subsequent development of diabetic complications. This study evaluated the ability of metformin (MET), berberine (BBR), and their combination to prevent GO-induced carbonyl stress in isolated rat liver mitochondria. Methods: Mitochondria (0.5 mg protein/mL) were i Read More

Background: Venlafaxine HCl is a selective serotonin reuptake inhibitor, which is given in the treatment of depression. The delivery of the drug at a controlled rate can be of great importance for a prolonged effect. Objective: The objective was to prepare and optimize the controlled release core in a cup matrix tablet of venlafaxine HCl using the combination of hydrophilic and hydrophobic polymers to prolong the effect with rate c Read More

Background: Metoclopramide hydrochloride (MCP), a derivative of para-aminobenzoic acid, which is a freely soluble drug, gets rapidly absorbed from the gastrointestinal tract and is used in the management of gastrointestinal disorders such as gastric stasis, gastroesophageal reflux and for the prevention of cancer chemotherapy induced emesis. Several brands of MCP are available in Saudi Arabia. Objective: The objective o Read More

Background: Rational drug use comprises aspects of prescribing, dispensing, and patient use of medicines for different health problems. This study is aimed to assess drug prescribing practices based on the world health organization prescribing indicators in Mizan-Tepi University teaching hospital. Methods: An institutional-based, retrospective, cross-sectional study was conducted to evaluate the prescribing practices in Miz Read More

Objective: The present research work focuses on experimental design assisted In-situ gel for fixed dose combination. Significance: Brinzolamide(BZ) BCS class II drug and Timolol Maleate (TM), a BCS class I drug is formulated for obtaining the sustained effect, increased ocular bioavailability and reduction of dose leading to better patient compliance. Methods: The material attributes were gelrite, hydroxy propyl Read More

Introduction: Modified Epley’s maneuver is the recommended treatment for the Posterior Canal (PC) BPPV. To enhance the efficacy of this maneuver, an easy to perform visual aid device (DizzyFIX) guided modified Epley’s maneuver was studied. Material and Methods: This prospective, double-blind, randomized study included consecutive patients with PC-BPPV based on clinical history, neuro-otological examination, and Read More

Background: Olmesartan medoxomil is an angiotensin II receptor blocker antihypertensive drug, which has low oral bioavailability because of poor aqueous solubility. Objective: The objective of the present research is the development and optimization of Olmesartan medoxomil loaded self-micro emulsifying drug delivery system by D-optimal mixture design to improve its dissolution rate. Methods: Solubility of Olmesartan m Read More