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image of Fabrication and Characterisation of Oral Fast-Dissolving Film of Metoprolol Succinate

Abstract

Introduction

Oral, fast-dissolving films are an excellent alternative. The purpose of adopting the solvent casting approach was to create a compelling oral film.

Methodology

HPMC E15 and sodium alginate polymers were chosen based on their compatibility. The produced films were evaluated in terms of organoleptic characteristics, weight, thickness, folding durability, tensile strength, drug content homogeneity, surface pH, disintegration time, and dissolution kinetics.

Results

Among the formulations, F2 had a disintegration time of 14.2 seconds and a phenomenal drug release of 98% in 5 minutes. As a result, formulation F2 emerged as the best option, demonstrating promising qualities for effective drug delivery.

Conclusion

These films are made of thin strips and are easily applied to the tongue or oral mucosal tissue. When they come into contact with saliva, they quickly hydrate and attach, resulting in rapid medicine administration. Fast-dissolving oral films are an excellent alternative for patients who have difficulty swallowing traditional drugs, such as pediatric, geriatric, bedridden, or developmentally impaired people. These films are made of thin strips and are easily applied to the tongue or oral mucosal tissue. When they come into contact with saliva, they quickly hydrate and attach, resulting in rapid medicine administration.

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2024-10-22
2024-11-26

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/content/journals/cdth/10.2174/0115748855329005241015093907
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Fabrication and Characterisation of Oral Fast-Dissolving Film of Metoprolol Succinate
Bentham Science Publishers ; https://doi.org/10.2174/0115748855329005241015093907
/content/journals/cdth/10.2174/0115748855329005241015093907
/content/journals/cdth/10.2174/0115748855329005241015093907
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  • Article Type:     Review Article
Keywords: Hypertension ; Fast Dissolving oral film ; HPMC E15 ; angina pectoris ; metoprolol succinate ; Sodium alginate

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