Current Drug Metabolism - Volume 19, Issue 2, 2018

Background: Hyperthermia has been proposed as a promising treatment modality for its advantageous profiles such as mini/non-invasiveness, good tolerability and cost-effectiveness. Quick development of nanotechnology in recent years has greatly broadened the application area of hyperthermia and endowed it with attractive new functions. This review aims to present an overview of different nanostructures mediat Read More

Background: Nano-oncology and interventional oncology are both rapidly emerging fields in cancer therapies. Synergistic combination of the both fields offers drastic improvements in performance and efficacy of cancer killing agents. Objective: This review is to overview the studies focusing on these two crossing fields and to give an overlook of their future development. Interventional techniques such as selective arterial cathet Read More

Background: Nanoparticle-based drug delivery systems hold great promise for the treatment of major diseases. However, their slow translation from bench to the clinic posts a concern. It is mainly attributed to the lack of suitable in vitro platforms for rapid and accurate screening of nanomedicine. Recent developments in microfluidic technologies have provided the possibility to reproduce the biomimetic blood vessel Read More

Background: With the rapid development of nanoparticles in drug delivery system, a lot of interest in the genotoxicity evaluation of nanocarriers has emerged currently. Here our emphasis was placed on the summary of studies on standard genotoxicity assays. Methods: We performed a PubMed/MEDLINE search for all publications in the English language related to assessment of genotoxicity of nanocarriers. A total of 45 Read More

Background: With the development of nanomaterials, nanoparticle-based therapeutics have found increasing application in various fields, including clinical and basic medicine. Real-time monitoring of nanoparticle-based therapeutics is considered critical to both pharmacology and pharmacokinetics. Methods: In this review, we discuss the different methods of real-time monitoring of nanoparticle-based therapeutics Read More

Background: In recent years, there has been an unprecedented expansion in the field of nanomedicine with the development of new nanoparticles for the diagnosis and treatment of cancer. It is also known that the use of nanocarriers as drug delivery systems for therapeutic or imaging agents can improve the pharmacological properties of ordinarily used compounds in cancer diagnosis and treatment. Objective: Advances in th Read More

Objective: We aimed at summarizing current evidence about mechanisms for potentially harmful effects of Proton Pump Inhibitors (PPIs). Methods: A Pubmed search was performed, and 207 studies concerning the relationship between use of PPIs and cardiovascular diseases, kidney impairment, nutritional disorders, fractures, infections, functional decline, and mortality were selected and reviewed. Results: PPIs may Read More

Background: In Physiologically Based Pharmacokinetic (PBPK) models, the most important input parameter is tissue-to-plasma partition coefficient (Kp). Over the years, several empirical methods have been developed to predict Kp in animals. Objectives: The objective of this study was to propose two allometric methods to predict Kp from experimentally determined in vivo volume of distribution at steady state (Vss). Meth Read More