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Volume 1, Issue 1
  • ISSN: 2542-579X
  • E-ISSN: 2542-5803

Abstract

Fibro-osseous lesions (FOLs) are a poorly defined but pathologically diverse group of lesions affecting the craniofacial bones and jaw. They are mostly characterized by the replacement of bone by a benign connective tissue matrix, which may contain foci of mineralization in the form of woven bone or cementum-like round acellular intensely basophilic structures. These lesions, although diverse, often present similar clinico-pathological and radiographic features. This often leads to difficulty in diagnosis and management. Definitive diagnosis is often reached only by incisional or excisional biopsy in resource-limited settings. Epidemiologically, the incidence and prevalence of different FOLs have been variable depending on the region. Reports from Africa indicated that FOLs make up to 10% of all oral biopsies, while others have given lower figures. A good understanding of the pathogenetic mechanism for FOLs is important, and state of the art molecular approaches are bound to improve the diagnosis and delineation of various entities that fall under the FOL category. Not least, the classification and nomenclature of these lesions by the World Health Organization (WHO) have changed significantly over the years. Hence, we have presented in this review a robust discussion on the pathobiology, emerging molecular markers, diagnostic challenges, future perspectives and recent changes to the classification/nomenclature of FOLs by WHO. In addition, we also discussed the diagnostic bottlenecks encountered during diagnosis of FOL in Africa.

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2019-05-01
2024-11-26

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References

  1. PrabhuS. SharanyaS. NaikP.M. Fibro-osseous lesions of the oral and maxillo-facial region: Retrospective analysis for 20 years.J. Oral Maxillofac. Pathol.20131713640
     [Google Scholar]
  2. AlawiF. Benign fibro-osseous diseases of the maxillofacial bones. A review and differential diagnosis.Am. J. Clin. Pathol.2002118S50S70
     [Google Scholar]
  3. AgarwalS.P. KumarS. SinghH.P. UsmaniS.A. Huge ossifying fibroma maxilla.Natl. J. Maxillofac. Surg.201562241243
     [Google Scholar]
  4. Tabareau-DelalandeF. CollinC. Gomez-BrouchetA. Diagnostic value of investigating GNAS mutations in fibro-osseous lesions: a retrospective study of 91 cases of fibrous dysplasia and 40 other fibro-osseous lesions.Mod. Pathol.2013267911921
     [Google Scholar]
  5. SpeightP. CarlosR. Maxillofacial fibroosseous lesions.Curr. Diagn. Pathol.200612110
     [Google Scholar]
  6. WhiteS. PharoahM.J. ORAL RADIOLOGY Principles and Interpretation.5th edSt. Louis, MO, USAMO Mosby Inc2004
     [Google Scholar]
  7. DorfmanH.D. New knowledge of fibro-osseous lesions of bone.Int. J. Surg. Pathol.2010183Suppl.62S65S
     [Google Scholar]
  8. BrannonR.B. FowlerC.B. Benign fibro-osseous lesions: A review of current concepts.Adv. Anat. Pathol.200083126143
     [Google Scholar]
  9. NevilleB. DammD.D. AllenC.M. ChiA. Oral and maxillofacial Pathology. 4th ed Neville B, Damm DD, Allen CM, Bouquot JE, editor NevilleB. DammD.D. AllenC.M. BouquotJ.E. PhiladelphiaWB Saunders2002
     [Google Scholar]
  10. EversoleR. SuL. ElMoftyS. Benign fibro-osseous lesions of the craniofacial complex. A review.Head Neck Pathol.200823177202
     [Google Scholar]
  11. LangdonJ.D. RapidisA.D. PatelM.F. Ossifying fibroma-one disease or six? An analysis of 39 fibro-osseous lesions of the jaws.Br. J. Oral Surg.1976141111
     [Google Scholar]
  12. OgunsaluC.O. LewisA. DoonquahL. Benign fibro-osseous lesions of the jaw bones in Jamaica: Analysis of 32 cases.Oral diseases200173155162
     [Google Scholar]
  13. EisenbergE. EisenbudL. Benign fibro-osseous diseases: Current concepts in historical perspective.Oral Maxillofac Clin Nor Am19979551555
     [Google Scholar]
  14. BustamanteE.V. AlbiolJ.G. AytesL.B. EscodaC.G. Benign fibro-osseous lesions of the maxillas: Analysis of 11 cases.Med Oral Patol Oral20081310E653E6
     [Google Scholar]
  15. WorawongvasuR. SongkampolK. Fibro-osseous lesions of the jaws: An analysis of 122 cases in Thailand.J. Oral Pathol. Med.2010399703708
     [Google Scholar]
  16. AlsharifM.J. SunZ.J. ChenX.M. WangS.P. ZhaoY.F. Benign fibro-osseous lesions of the jaws: A study of 127 Chinese patients and review of the literature.Int. J. Surg. Pathol.2009172122134
     [Google Scholar]
  17. KoviJ. LaingW.N. Tumours of the mandible and maxilla in accra, ghana.Cancer196619913011307
     [Google Scholar]
  18. AbdulaiA. GyasiR.K. IddrissuM.I. Benign fibro-osseous lesions of the facial skeleton: An analysis of 52 cases seen at the korle bu teaching hospital.Ghana Med. J.200438396100
     [Google Scholar]
  19. AjikeS.O. ArotibaJ.T. AdebolaR.A. LadehindeA. AmoleI.O. Spectrum of oral and maxillofacial surgical procedures in Kano, Nigeria.West Indian Med. J.2005545325328
     [Google Scholar]
  20. AdebayoE. AjikeS.O. AbiteM.G. Audit of oral and maxillofacial surgical conditions seen at port harcourt nigeria.Annals of Afr. Med.2008712934
     [Google Scholar]
  21. MacDonald-JankowskiD.S. Fibro-osseous lesions of the face and jaws.Clin. Radiol.20045911125
     [Google Scholar]
  22. AnithaN. SankariS.L. MalathiL. KarthickR. Fibrous dysplasia-recent concepts.J. Pharm. Bioallied Sci.20157Suppl. 1S171S172
     [Google Scholar]
  23. RiminucciM. RobeyP.G. SaggioI. BiancoP. Skeletal progenitors and the GNAS gene: Fibrous dysplasia of bone read through stem cells.J. Mol. Endocrinol.2010456355364
     [Google Scholar]
  24. MahoreA. RangarajanV. PatilM. ShendarkarA. Fibrous dysplasia with secondary osteosarcoma - A rare presentation of a common disease.J. Neurol.2016643544545
     [Google Scholar]
  25. TuranS. BastepeM. GNAS spectrum of disorders.Curr. Osteoporos. Rep.2015133146158
     [Google Scholar]
  26. JourG. OultacheA. SadowskaJ. GNAS mutations in fibrous dysplasia: A comparative study of standard sequencing and locked nucleic acid pcr sequencing on decalcified and nondecalcified formalin-fixed paraffin-embedded tissues.Appl. Immunohistochem. Mol. Morphol.2016249660667
     [Google Scholar]
  27. BiancoP. RiminucciM. MajolagbeA. Mutations of the GNAS1 gene, stromal cell dysfunction, and osteomalacic changes in non-McCune-Albright fibrous dysplasia of bone.J. Bone Miner. Res.2000151120128
     [Google Scholar]
  28. DiCaprioM.R. EnnekingW.F. Fibrous dysplasia. Pathophysiology, evaluation, and treatment.J. Bone Joint Surg. Am.200587818481864
     [Google Scholar]
  29. CandeliereG.A. GlorieuxF.H. Prud’hommeJ. St-ArnaudR. Increased expression of the c-fos proto-oncogene in bone from patients with fibrous dysplasia.N. Engl. J. Med.19953322315461551
     [Google Scholar]
  30. ToyosawaS. YukiM. KishinoM. Ossifying fibroma vs fibrous dysplasia of the jaw: Molecular and immunological characterization.Mod. Pathol.2007203389396
     [Google Scholar]
  31. MarieP.J. Cellular and molecular basis of fibrous dysplasia.Histol. Histopathol.2001163981988
     [Google Scholar]
  32. WaldronC.A. Fibro-osseous lesions of the jaws.J. Oral Maxillofac. Surg.1993518828835
     [Google Scholar]
  33. MelroseR. The clinico-pathologic spectrum of cemento-osseous dysplasia.Oral Maxillofac. Surg. Clin. North Am.19979643654
     [Google Scholar]
  34. EversoleL.R. LeiderA.S. NelsonK. Ossifying fibroma: a clinicopathologic study of sixty-four cases.Oral Surg. Oral Med. Oral Pathol.1985605505511
     [Google Scholar]
  35. SawyerJ.R. TrykaA.F. BellJ.M. BoopF.A. Nonrandom chromosome breakpoints at xq26 and 2q33 characterize cemento-ossifying fibromas of the orbit.Cancer1995761018531859
     [Google Scholar]
  36. DalcinP. SciotR. FossionE. VandammeB. VandenbergheH. Chromosome-abnormalities in cementifying fibroma.Cancer Genet. Cytogenet.1993712170172
     [Google Scholar]
  37. MonfortJ. SalaD.R. RomeroA.B. DuroJ.C. MaymoJ. CarbonellJ. Epidemiological, clinical, biochemical, and imaging characteristics of monostotic and polyostotic Paget’s disease.Bone1999245Suppl.13S14S
     [Google Scholar]
  38. RebelA. MalkaniK. BasleM. BregeonC. PatezourA. FilmonR. Ultrastructural characteristics of osteoclasts in Paget’s disease.Rev. Rhum. Mal. Osteoartic.19744112767771
     [Google Scholar]
  39. MillsB.G. SingerF.R. Nuclear inclusions in Paget’s disease of bone.Science19761944261201202
     [Google Scholar]
  40. MeeA.P. MayC. BennettD. SharpeP.T. Generation of multinucleated osteoclast-like cells from canine bone marrow: Effects of canine distemper virus.Bone19951714755
     [Google Scholar]
  41. ReddyS.V. KuriharaN. MenaaC. Osteoclasts formed by measles virus-infected osteoclast precursors from hCD46 transgenic mice express characteristics of pagetic osteoclasts.Endocrinology2001142728982905
     [Google Scholar]
  42. KuriharaN. ReddyS.V. MenaaC. AndersonD. RoodmanG.D. Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype.J. Clin. Invest.20001055607614
     [Google Scholar]
  43. RalstonS.H. Clinical practice. Paget’s disease of bone.N. Engl. J. Med.20133687644650
     [Google Scholar]
  44. BansalS. ShettyS. BablaniD. KulkarniS. KumarV. DesaiR. Florid osseous dysplasia.J. Oral Maxillofac. Pathol.2011152197200
     [Google Scholar]
  45. AlsufyaniN.A. LamE.W. Cemento-osseous dysplasia of the jaw bones: Key radiographic features.Dentomaxillofac. Radiol.2011403141146
     [Google Scholar]
  46. RaubenheimerE.J. NoffkeC.E. BoyS.C. Osseous dysplasia with gross jaw expansion: A review of 18 lesions.Head Neck Pathol.2016104437443
     [Google Scholar]
  47. KramerI. PindborgJ.J. ShearM. Histological typing of odontogenic tumors.In: springer-verlag. Berlin, Germany 992; pp. 29-31.
     [Google Scholar]
  48. GrewalH.K. GoelP. BatraR. ChopraS. A tender swelling of the left posterior mandible: An unusual case.J. Oral Maxillofac. Pathol.2014182332
     [Google Scholar]
  49. Florencio-SilvaR. SassoG.R.D. Sasso-CerriE. SimoesM.J. CerriP.S. Biology of bone tissue: structure, function, and factors that influence bone cells.BioMed Res. Int.20152015421746
     [Google Scholar]
  50. WassermanJ.D. TomlinsonG.E. DrukerH. Multiple endocrine neoplasia and hyperparathyroid-jaw tumor syndromes: Clinical features, genetics, and surveillance recommendations in childhood.Clin. Cancer Res.20172313E123E32
     [Google Scholar]
  51. ShibataY. YamazakiM. TakeiM. UchinoS. SakuraiA. KomatsuM. Early-onset, severe, and recurrent primary hyperparathyroidism associated with a novel CDC73 mutation.Endocr. J.2015627627632
     [Google Scholar]
  52. MeleM. RolighedL. JespersenM. RejnmarkL. ChristiansenP. Recurrence of hyperparathyroid hypercalcemia in a patient with the hrpt-2 mutation and a previous parathyroid carcinoma in hyperparathyroidism-jaw tumor syndrome.Int. J. Endocrinol. Metab.2016142
     [Google Scholar]
  53. FellerL. WoodN.H. KhammissaR.A. LemmerJ. RaubenheimerE.J. The nature of fibrous dysplasia.Head Face Med.2009522
     [Google Scholar]
  54. AlbrightF. ButlerA.M. Syndrome characterised by osteitis fibroma disseminate, areas of pigmentation and endocrine dysfunction, with precocious puberty in females report of five cases.N. Engl. J. Med.1937216727746
     [Google Scholar]
  55. PerdigaoP.F. PimentaF.J.G.S. CastroW.H. De MarcoL. GomezR.S. Investigation of the G(S)alpha gene in the diagnosis of fibrous dysplasia.Int. J. Oral Maxillofac. Surg.2004335498501
     [Google Scholar]
  56. IdowuB.D. Al-AdnaniM. O’DonnellP. A sensitive mutationspecific screening technique for GNAS1 mutations in cases of fibrous dysplasia: The first report of a codon 227 mutation in bone. Histopathology 2007; 50(6): 691-704
    [Google Scholar]
  57. LiY.C. SamuvelD.J. SundararajK.P. Lopes-VirellaM.F. HuangY. IL-6 and high glucose synergistically upregulate mmp-1 expression by u937 mononuclear phagocytes via ERK1/2 and JNK Pathways and c-Jun.J. Cell. Biochem.20101101248259
     [Google Scholar]
  58. Mechta-GrigoriouF. GeraldD. YanivM. The mammalian Jun proteins: redundancy and specificity.Oncogene2001201923782389
     [Google Scholar]
  59. SchuringaJ.J. TimmerH. LuttickhuizenD. VellengaE. KruijerW. c-Jun and c-Fos cooperate with STAT3 in IL-6-induced transactivation of the IL-6 respone element (IRE).Cytokine20011427887
     [Google Scholar]
  60. Dal CinP. SciotR. BrysP. Recurrent chromosome aberrations in fibrous dysplasia of the bone: A report of the CHAMP study group. CHromosomes And MorPhology.Cancer Genet. Cytogenet.200012213032
     [Google Scholar]
  61. LiuY. WangH. YouM. Ossifying fibromas of the jaw bone: 20 cases.Dentomaxillofac. Radiol.20103915763
     [Google Scholar]
  62. BarnesL. EvesonJ.W. ReichartP. SidranskyD. World health organization classification of tumours. Pathology & Genetics of Head and Neck Tumours.Lyon, FranceIARC Press2005
     [Google Scholar]
  63. YoonJ.H. KimJ. LeeC.K. ChoiI.J. Clinical and histopathological study of fibro-osseous lesions of the jaws.Yonsei Med. J.1989302133143
     [Google Scholar]
  64. SuL. WeathersD.R. WaldronC.A. Distinguishing features of focal cemento-osseous dysplasias and cemento-ossifying fibromas: I. A pathologic spectrum of 316 cases.Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.1997843301309
     [Google Scholar]
  65. NwizuN. AguirreA. ChenF. Diagnostic challenges of benign fibroosseous lesions and psammomatoid meningiomas of the craniofacial region: A comparative review of their clinico-pathological features.N. Am. J. Med. Sci.2010311723
     [Google Scholar]
  66. MaheshwariP. RaoN.N. RadhakrishnaR. Histochemical evaluation of stromal components in fibrous dysplasia, central ossifying fibroma and juvenile ossifying fibroma affecting the Jaw bones.J. Dent. Res.20142137
     [Google Scholar]
  67. ObisesanA.A. LagundoyeS.B. DaramolaJ.O. AjagbeH.A. OluwasanmiJ.O. The radiologic features of fibrous dysplasia of the craniofacial bones.Oral Surg. Oral Med. Oral Pathol.1977446949959
     [Google Scholar]
  68. HuvosA. Fibrous dysplasia and Ossifying fibroma Bone Tumors Diagnosis, Treatment and Prognosis.2nd edPhiladelphia W.B. Saunders Company1991
     [Google Scholar]
  69. SobralA. HerculanoC.L.T. BalabanR. Evaluation of calcium íon deposition in benign fibro-osseous lesions: A histochemical study.Rev Cir Traumatol Buco-Maxilo-fac2009928188
     [Google Scholar]
  70. GulatiA. RaoN.N. RadbakrishnanR.A. Fibrous dysplasia and ossifying fibroma.J. Clin. Exp. Dent.201134297302
     [Google Scholar]
  71. SoyeleO. EffiomO.A. OdukoyaO. Masson’s trichrome and agnor study of fibrous dysplasia and ossifying fibroma in lagos university teaching hospital patients world.J. Pathol.2013294101
     [Google Scholar]
  72. EslamiM. BaghaeeF. AlaeddiniM. Diagnostic value of silver stained nucleolar organizer regions in osteosarcoma, fibrous dysplasia and ossifying fibroma of the jaws.Acta Med. Iran.2005434243248
     [Google Scholar]
  73. WilliamsA.O. BrowneR.M. AkinosiJ.O. Fibro-osseous lesions of the jaw in Nigeria.J. Natl. Med. Assoc.1974663185191
     [Google Scholar]
  74. GarciaB. CaldeiraP.C. JohannA.C.B.R. SousaS.C.O.M. Comparative cellular proliferative activity in ossifying and odontogenic fibromas.Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.20082712
     [Google Scholar]
  75. MakiM. SaitohK. HoriuchiH. MorohoshiT. FukayamaM. MachinamiR. Comparative study of fibrous dysplasia and osteofibrous dysplasia: Histopathological, immunohistochemical, argyrophilic nucleolar organizer region and DNA ploidy analysis.Pathol. Int.2001518603611
     [Google Scholar]
  76. YoshikawaH. NakaseT. MyouiA. UedaT. Bone morphogenetic proteins in bone tumors.J. Orthop. Sci.200493334340
     [Google Scholar]
  77. MouselhyY. DrazA.I. El-ShafeiM.M. El-RoubyD.H. Comparative immunohistochemical study on osteocalcin expression in fibrous dysplasia and ossifying fibroma.Int J Acad Res Part A.201351913
     [Google Scholar]
  78. MohantyS. GuptaS. KumarP. SriramK. GulatiU. Retrospective analysis of ossifying fibroma of jaw bones over a period of 10 years with literature review.J. Maxillofac. Oral Surg.2014134560567
     [Google Scholar]
  79. GuerinM. ThariatJ. OualiM. A new subtype of high-grade mandibular osteosarcoma with RASAL1/MDM2 amplification.Hum. Pathol.2016507078
     [Google Scholar]
  80. ShinS.J. LeeS.J. KimS.K. Frequency of GNAS R201H substitution mutation in polyostotic fibrous dysplasia: Pyrosequencing analysis in tissue samples with or without decalcification.Scientific reports2017712836
     [Google Scholar]
  81. SciubbaJ.J. YounaiF. Ossifying fibroma of the mandible and maxilla: Review of 18 cases.J. Oral Pathol. Med.1989186315321
     [Google Scholar]
  82. SummerlinD.J. TomichC.E. Focal cemento-osseous dysplasia: A clinicopathologic study of 221 cases.Oral Surg. Oral Med. Oral Pathol.1994785611620
     [Google Scholar]
  83. LawalA. AdisaA.O. LasisiT.J. Florid cement-osseous dysplasia: A report of two cases seen at the university college hospital ibadan.Ann. Ib. Postgrad. Med.201134547
     [Google Scholar]
  84. Macdonald-JankowskiD.S. Focal cemento-osseous dysplasia: A systematic review.Dentomaxillofac. Radiol.2008376350360
     [Google Scholar]
  85. EtteA. HaeffnerG. BambaM. CisseG. FakhryK. Surgery of ossifying fibromas in the Ivory Coast.Rev. Laryngol. Otol. Rhinol. (Bord.)198010111-12513526
     [Google Scholar]
  86. DaramolaJ.O. AjagbeH.A. ObisesanA.A. LagundoyeS.B. OluwasanmiJ.O. Fibrous dysplasia of the jaws in Nigerians.Oral Surg. Oral Med. Oral Pathol.1976423290300
     [Google Scholar]
  87. AdekeyeE.O. EdwardsM.B. GoubranG.F. Fibro-osseous lesions of the skull, face and jaws in Kaduna, Nigeria.Br. J. Oral Surg.19801815772
     [Google Scholar]
  88. LasisiT.J. AdisaA.O. OlusanyaA.A. Fibro-osseous lesions of the jaws in Ibadan, Nigeria.Oral Health Dent. Manag.20141314144
     [Google Scholar]
  89. SuleA. IyogunC.A. AdeyemiT.E. Pattern of fibro osseous lesions of the jaws in kano, Northern Nigeria.J Dent Oral Health2017357476
     [Google Scholar]
  90. CookJ. SinghP. Tumours of the Jaw.East Afr. Med. J.195633383386
     [Google Scholar]
  91. SlootwegP.J. MullerH. Differential diagnosis of fibro-osseous jaw lesions. A histological investigation on 30 cases.J. Craniomaxillofac. Surg.1990185210214
     [Google Scholar]
  92. AnandS.V. DaveyW.W. CohenB. Tumours of the jaw in West Africa. A review of 256 patients.Br. J. Surg.19675411901917
     [Google Scholar]
  93. MuwaziL.M. KamulegeyaA. The 5-year prevalence of maxillofacial fibro-osseous lesions in Uganda.Oral Dis.2015211e79e85
     [Google Scholar]
  94. MoshyJ. DimbaE. OchollaT. ChindaM. Characteristic radiological and histological patterns of fibrous dysplasia and ossifying fibroma of the jaws at University of Nairobi Dental Teaching Hospital.Surg. Sci.20123189193
     [Google Scholar]
  95. CookeB. Benign fibro-osseous enlargements of the jaws: Part I and II.Br. Dent. J.1957103114, 49-59
     [Google Scholar]
  96. PecaroB.C. Fibro-osseous lesions of the head and neck.Otolaryngol. Clin. North Am.1986193489496
     [Google Scholar]
  97. HamnerJ.E.III ScofieldH.H. CornynJ. Benign fibro-osseous jaw lesions of periodontal membrane origin. An analysis of 249 cases.Cancer1968224861878
     [Google Scholar]
  98. GowingN.F.C. International histological classification of tumours no. 5: Histological typing of odontogenic tumours. Jaw cysts, and allied lesions.J. Clin. Pathol.19722510917
     [Google Scholar]
  99. PindborgJ.J.K.I. TorloniH. Histological typing of odontogenic tumours, jaw cysts, and allied lesions.nternational histological classification of tumours. World Health Organization Book 5 Geneva, Switzerland
    [Google Scholar]
  100. KramerI.R. PindborgJ.J. ShearM. The WHO histological typing of odontogenic tumours. A commentary on the second edition. Cancer 1992; 70(12): 2988-94.
     [Google Scholar]
  101. WrightJ.M. VeredM. Update from the 4th edition of the world health organization classification of head and neck tumours: odontogenic and maxillofacial bone tumors. Head Neck Pathol 2017; 11(1): 68-77
     [Google Scholar]
  102. AdeolaH.A. SoyeleO.O. AdefuyeA.O. JimohS.A. ButaliA. Omics-based molecular techniques in oral pathology centred cancer: Prospect and challenges in Africa.Cancer Cell Int.20171761
     [Google Scholar]
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Molecular Diagnosis of Fibro-osseous Lesions of the Oral and Maxillofacial Region: A Tale from Africa
Curr. Dentistry 1, 3 (2019); https://doi.org/10.2174/2542579X01666180613075855
/content/journals/cdent/10.2174/2542579X01666180613075855
/content/journals/cdent/10.2174/2542579X01666180613075855
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  • Article Type:     Review Article
Keyword(s): Africa; bone dysplasia; Fibro-osseous lesions; fibrous dysplasia; molecular diagnosis; ossifying fibroma

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