Combinatorial Chemistry & High Throughput Screening - Volume 25, Issue 2, 2022

The precise and exquisite architecture of the retina is directly related to vision. Therefore, any mechanisms associated with disruption of retinal structure could affect the quality of vision. A large number of studies indicated that several cellular and molecular processes are involved in retina pathogenesis. Among different risk factors reported as important players in retina diseases, deregulation of epigenetic contributors has Read More

Background: Atrial fibrillation (AF) is the most common persistent arrhythmia and an important factor leading to cardiovascular morbidity and mortality. Several key genes and diagnostic markers have been discovered with the development of advanced modern molecular biology techniques, but the etiology and pathogenesis of AF remained unknown. Methods: In this study, three-chip-seq data sets and an RNA-se Read More

Background: Hypertension is one of the most important health problems in the world and irbesartan and amlodipine are used in combination in various dosages for the treatment of high blood pressure. Objective: The aim of this study is to develop a fast, easy, sensitive, accurate, and precise squarewave voltammetry method for simultaneous determination of irbesartan and amlodipine besylate from pharmaceutical f Read More

Background: The genus Thymus is one of the well-known members of the Lamiaceae, comprising about 215 species. It is a polymorphic genus in this family. Therefore, possible differences in chemical composition among polymorphs may result in differences in their biological activities. Objective: This study was designed to specify chemical composition in order to assess antioxidant activities and to characterize active co Read More

Background: Due to the importance of fused chromene motifs in bioactive compounds, the current research aimed to explore novel methods for the construction of heterocyclic scaffolds. Regarding the attractive features of developing novel methodological approaches in the presence of heterogeneous nanocatalysts, we will try to synthesize 4-aryl-3,4-dihydro-2H,5H-pyrano[3,2- c]chromene-2,5-diones and 8-aryl-7,8-dihy Read More

Background: Dihydroquinazolinone derivatives are an important family of fused heterocyclic compounds which possess a wide range of biological, medicinal and pharmacological properties such as anti-tumor, anti-biotic, diuretic, analgesic, anti-hypertonic, anti-pyretic, antidepressant, anti-histamine and vasodilation activities. Introduction: So far, some acid catalysts, e.g. p-toluenesulfonic acid, silica sulfuric acid, zinc(II) perf Read More

Objective: The research work aims to synthesize novel series of hydrazones and antioxidant screening. It also aims to evaluate the binding affinities and in silico methods for identifying possible drug targets of synthesized compounds. Methods: This report briefly explains the synthesis of a novel series of hydrazones. It was synthesized via. hydrazinolysis of esters to obtain hydrazide, treated with aldehyde and acetophenone to ge Read More

Aim and Objectives:This research work deals with the highly selective oxidation of benzyl alcohol to benzaldehyde by palladium doped graphene oxide catalyst, which was synthesized by a modified Hummer’s method. The effect of reaction parameters like temperature, time and catalyst loading were studied. It was found that fine-tuning of reaction temperature and presence of a small amount of benzyl alcohol in a produ Read More

Background: Malaria is caused by different species of Plasmodium; among which P. falciparum is the most severe. Coptis teeta is an ethnomedicinal plant of enormous importance for tribes of northeast India. Objective: In this study, the antimalarial activity of the methanol extracts of Coptis teeta was evaluated in vitro and lead identification was carried out via in silico study. Methods: On the basis of the in vitro results, in silico anal Read More

Background: Solubility/dissolution is said to be the key factor that influences the oral bioavailability of drug and is also the rate limiting step in formulation development. Objective: Hydrochlorothiazide (HCZ) is a BCS Class IV drug with low solubility and low permeability. The present work aimed to increase the solubility of hydrochlorothiazide using blends of natural and synthetic hydrotropes. Methods: Two hydrotropes one Read More

Background: Bacterial infection is a frequent complication in cancer and immunocompromised patients. The emergence of antibiotic resistance is a significant health problem and cancer patients are at risk of repeated infections with drug-resistant bacteria. Objective: This investigation aimed to identify predictors of repeat infections of Escherichia coli and Klebsiella pneumoniae and drug resistance in cancer patients admitted to Read More

Background: Hepatitis C Virus (HCV) is one of the serious health issues affecting onethird of the world’s population. The high variations of the HCV genome are ascribed to quick replication by NS5B polymerase and are thus the most attractive target for developing anti-HCV agents. Objective: The current study aimed to discover novel phytochemicals that harbor the potential of NS5B polymerase inhibition. Methods: In this com Read More