Combinatorial Chemistry & High Throughput Screening - Volume 25, Issue 13, 2022

Multi-drug resistance (MDR) is characterized by the resistance of tumor cells to some antitumor drugs with different structures and mechanisms after the use of a single chemotherapy drug or even the first use of the drug. Notably, MDR has become the largest obstacle to the success of gastric cancer chemotherapies. Non-coding RNAs are defined as a class of RNAs that do not have the ability to code proteins. They are Read More

Cancer is a vast form of the disease that can begin in almost any organ or tissue of the body when abnormal cells grow uncontrollably and attack nearby organs. The traditional approaches to cancer diagnosis and drug development have certain limitations, and the outcomes achieved through the traditional approaches applied to cancer diagnosis and drug development are not quite promising. Artificial intelligence is not new to Read More

Background: Ermiao San, one of the Chinese medicine formulas, has been widely used to treat rheumatoid arthritis (RA). Our previous study has demonstrated that Ermiao San is effective in treating RA. However, its pharmacological mechanisms remain unclear. Therefore, the purpose of this study was to decipher the potential mechanism of action of Ermiao San in rheumatoid arthritis (RA) by bioinformatics, network pharmac Read More

Aim: This study aims to comprehensively analyse the Ribosomal Protein S6 Kinase A4 (RPS6KA4) and determine the prognostic value for hepatocellular carcinoma (HCC). Background: Liver cancer is a common type of tumor worldwide, and HCC accounts for about 75 to 85% of all primary liver cancer cases. The Ribosomal S6 protein kinases (RSK) family plays an important regulatory role in cell growth, movement, Read More

Background: Fidgetin-like 1 (FIGNL1), a subfamily member of ATPases, is associated with diverse cellular activities (AAA proteins). FIGNL1 is involved in DNA repair. However, the latest study has indicated that FIGNL1 plays a crucial role in the occurrence and development of malignant tumors. Methods: FIGNL1 expression was analyzed via Oncomine and GEPIA databases, and its prognostic potential was analyzed using OncoLnc Read More

Background and Objective: To explore the molecular mechanism by which Shengmaiyin (Codonopsis pilosula) (SMY) improves isoproterenol (ISO)-induced heart failure (HF) in rats via a traditional Chinese medicine (TCM) integrated pharmacology research platform, The Chinese Medicine Integrated Pharmacology Platform (TCMIP V2.0). Method: The chemical constituents and drug targets of SMY medicines were identified Read More

Background: Hepatocellular carcinoma (HCC) is inflammation-associated cancer with high incidence and poor prognosis. In the last decade, immunotherapy has become an important strategy for managing HCC. Objective: This study aimed to establish an immune-related gene signature for predicting prognosis and immunotherapy response in HCC. Methods: We identified immune-related differentially expressed genes (IR Read More

Background: Immune-related long noncoding RNAs (lncRNAs) play an important role in the development of cancer. This study aimed to identify immune-related lncRNAs in thyroid cancer (THCA) and develop a prognostic model for THCA. Methods: We downloaded immune-related gene sets from the Gene Set Enrichment Analysis (GSEA) website and obtained THCA gene expression and clinical data from The Cancer Genome Read More

Background: Septic shock is a frequent and costly problem among patients in the pediatric intensive care unit (PICU) and is associated with high mortality and devastating survivor morbidity. In this study, we aimed to screen candidate biomarkers and potential therapeutic targets for septic shock. Methods: GSE26440 dataset was downloaded from Gene Expression Omnibus (GEO), including 32 normal controls and 98 childre Read More

Objective: The potential pathogenesis of LUAD remains largely unknown. In the present study, we evaluated the competing endogenous RNA (ceRNA) regulatory network and tumorinfiltrating immune cells in LUAD. Methods: We obtained the RNA profiles and corresponding clinical information of LUAD patients from the TCGA data portal, and identified differentially expressed mRNAs (DEmRNAs), lncRNAs (DElncRNAs Read More

Background: Lung adenocarcinoma (LUAD) is a highly heterogeneous malignant tumor. Therefore, it is necessary to find predictive biomarkers related to the prognosis and immune infiltration of lung adenocarcinoma, which may provide an effective theoretical basis for its clinical treatment. Objective: This study aimed to evaluate whether the expression level of PHD3 in lung adenocarcinoma (LUAD) is related to immunity. Me Read More

Background: A xiaoqinglong decoction (XQLD) has been proven effective in treating severe coronavirus disease 2019 (COVID-19) cases; however, the mechanism remains unclear. Objective: In the current study, we used network pharmacology and molecular docking technology to identify the effective components, potential targets, and biological pathways of XQLD against COVID-19. Methods: Public databases were searched t Read More

Background and Objective: SPC24 was reported to be correlated with the development of many cancers. However, its role in renal cancer was unclear. Our aim was to explore the role of SPC24 in kidney renal clear cell carcinoma (KIRC) and kidney renal papillary cell carcinoma (KIRP) in types of renal cancer. Methods: SPC24 expressions in KIRC and KIRP were firstly analyzed. Subsequently, the correlation between SPC24 Read More

Objective: The present study aims to assess a proposed treatment approach or therapy for periodontitis by using the in-silico technique. The proposed treatment strategy offers a singular vehicular system consisting of minocycline (antibiotic), celecoxib (selective COX-II inhibitor), doxycycline hyclate (matrix metalloproteinase inhibitor), and hydroxyapatite (osteogenic agent). Material and Methods: Molecular dockin Read More