Combinatorial Chemistry & High Throughput Screening - Volume 13, Issue 10, 2010

Medicinal herbs have been used to treat human diseases in China for thousands of years. There has been great interest in the research and development of bioactive components from herbal medicines. Significant pharmacological properties have been demonstrated for many herbs over recent decades. Not only important in China, herbal preparations are becoming increasingly popular in Europe and North America Read More

Throughout the centuries, traditional Chinese medicine has been a rich resource in the development of new drugs. Modern drug discovery, which relies increasingly on automated high throughput screening and quick hit-to-lead development, however, is confronted with the challenges of the chemical complexity associated with natural products. New technologies for biological screening as well as library building are in great d Read More

The epidermal growth factor receptor (EGFR) has become an important molecular target in cancer therapy. Various small molecules and therapeutic antibodies targeting EGFR family members have been developed during recent years and are established in clinical oncology. However, increasing clinical application of EGFR tyrosine kinase inhibitors has resulted in the development of resistance to EGFR-targeting drugs d Read More

Traditional Chinese medicines (TCMs), a key branch of natural medicines, play an important role in the treatment of diseases because of their reliable clinical performance. Identification of their active compounds constitutes a bottleneck in the development of TCMs. Screening and analysis of active compounds is a challenge in TCM research. This review summarizes recent progress in the development of biological fingerprin Read More

Traditional Chinese medicines (TCMs) have been used for disease prevention and therapy in China for a long history and are becoming increasingly popular over the world. However, TCMs are complex mixtures and contain usually hundreds of chemically different constituents, which make the quality control of crude drugs and their medical preparations extremely difficult. Therefore, better analytical strategies to assure their ef Read More

Traditional Chinese medicine (TCM) has been used for more than 4000 years. By comparison with large combinatorial chemistry libraries and natural products of the West for high-throughput screening (HTS) of new drugs discovery, an advantage of TCM is that the preparation has clear efficacies on the therapy of some diseases. Although the effective components are not clear, the clear efficacies of TCM have been iden Read More

The use of chromatographic fingerprints from herbal products where the whole chromatographic profile is applied, is an approach to evaluate the quality of the investigated product. In this paper, recent developments in the set-up and data analysis of chromatographic fingerprints for herbal products are discussed. First, different set-ups for fingerprint development are reviewed. Prior to the fingerprint development, a suitable Read More

At present, high throughput screening (HTS) programs in drug discovery rely mainly on compound libraries from combinational chemistry. Similarly, natural flora has been used as a prominent origin for new and potent herbal drugs. Herbal medicines have been used worldwide for thousands of years to cure many diseases. As such, herbal secondary metabolites show a remarkable structural diversity that supplements chemicall Read More

Counter-current chromatography (CCC) is a unique support-free liquid-liquid partition chromatography winning wide applications in the separation of various components from natural or synthetic mixtures. It has been one of the prime methods for isolating compounds from Traditional Chinese Medicines (TCM) and other comprehensive natural products. Although early CCC models produced a long-standing false image that CCC Read More

Chromatographic fingerprinting technique of traditional Chinese medicine (TCM) has proved to be a comprehensive strategy for assessing the intact quality of herbal medicine. In general, one could use the chromatographic techniques to obtain a relatively complete picture of herbal medicines, which are in common called chromatographic fingerprints of herbal medicines to represent the so-called phytoequivalence. Read More

Traditional Chinese medicines (TCMs) are generally mixtures of herbal plants or extracts which comprise hundreds of different constituents with widely difference in the content and physiochemical properties. In order to analyze bioactive compounds in TCMs and control the quality, a large number of analytical tools have been developed, among which capillary electrophoresis (CE) has become a powerful technique with incr Read More

Ping Zhou holds an Honors MS in Botany from the Wuhan University, China (1994) and a Ph.D. in Analytical Chemistry (1997) from the same university. From 1997 to 1998, he worked at the Faculty of Pharmaceutical Sciences, University of Tokushima, Japan, as a foreign researcher in Pharmacognosy. He joined the Wuhan University as an associate professor in 1999. From 2008-2009, he worked at the Institute for Biolo Read More

Due to an oversight on the part of the authors, Emirhan Nemutlu, Sedef Kir, Hakan Eroglu, Doruk Katlan, Aykut Ozek, Ozgur Ozyuncu and M. Sinan Beksac, incorrect name of one of the co-author was published in the article entitled “Comparison of Pharmacokinetic Profiles of Moxifloxacin in Caesarean versus Non-Pregnant Sectioned Women by Fully Validated HPLC with Fluorescence Detection”, Combinatorial Chemistry & Hig Read More