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2000
Volume 13, Issue 10
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

Throughout the centuries, traditional Chinese medicine has been a rich resource in the development of new drugs. Modern drug discovery, which relies increasingly on automated high throughput screening and quick hit-to-lead development, however, is confronted with the challenges of the chemical complexity associated with natural products. New technologies for biological screening as well as library building are in great demand in order to meet the requirements. Here we review the developments in these techniques under the perspective of their applicability in natural product drug discovery. Methods in library construction, component characterization, biological evaluation, and other screening approaches including NMR and X-ray diffraction are discussed.

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/content/journals/cchts/10.2174/138620710793360257
2010-12-01
2025-07-03
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