Skip to content
2000
Volume 13, Issue 10
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

The epidermal growth factor receptor (EGFR) has become an important molecular target in cancer therapy. Various small molecules and therapeutic antibodies targeting EGFR family members have been developed during recent years and are established in clinical oncology. However, increasing clinical application of EGFR tyrosine kinase inhibitors has resulted in the development of resistance to EGFR-targeting drugs due to the selection of EGFR-mutated variants. This phenomenon forced the search for novel EGFR inhibitors with activity towards EGFR-mutant tumors. This review describes recent achievements in natural products derived from medicinal plants as novel EGFR inhibitors.

Loading

Article metrics loading...

/content/journals/cchts/10.2174/138620710793360266
2010-12-01
2025-07-04
Loading full text...

Full text loading...

/content/journals/cchts/10.2174/138620710793360266
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test