Current Chemical Biology - Volume 13, Issue 3, 2019

Background: Immunomodulation-based therapy has achieved a breakthrough in the last decade, which stimulates the passion of searching for potential immunomodulatory substances in recent years. Objective: Marine natural products are a unique source of immunomodulatory substances. This paper summarized the emerging marine natural small-molecules and related synthesized derivatives with immunomod Read More

Background: Objective: Various natural gums can be synergistically used in nanoparticulate drug delivery systems to treat cardiovascular diseases. Nanotechnology has been integrated into healthcare in terms of theranostics. In this review, we consider various natural gums that can be used for the preparation of nanoparticles and their role to treat cardiovascular disease. Methods: Nanoparticles can carry drugs at nanoscales an Read More

Background: Takeda G-protein receptor 5 (TGR5) via glucagon-like peptide release and insulin signaling underlies antidiabetic roles of TGR5 agonists. Chromolaena Odorata- derived flavonoid-5,7-dihydroxy-6-4-dimethoxyflavanone (COF) has been identified as (TGR5) agonist. The structural basis for their interaction has not been studied. Objective: This study aimed at providing both structural and dynamic insights i Read More

Background: Silver nanoparticles have a profound role in the field of high sensitivity biomolecular detection, catalysis, biosensors and medicine. In the present study, aqueous extract of Dracocephalum kotschyi has been used for the synthesis of silver nanoparticles. Objective: In this study, we evaluated the antioxidant features and the possibility of biosynthesis of AgNPs using an aqueous extract of Dracocephalum kotschyi and Read More

Background: Cancer is an extremely fast, unrestrained and pathological propagation of cells. Yet there is no cancer treatment that is 100% efficient against scattered cancer. Heterocycles have been considered as a boon to treat several cancers of which pyrimidine is a core nucleus and holds an important place in cancer chemotherapy which is reflected in the use of drugs such as 5-fluorouracil, erlotinib, gefitinib and caneratinib. Read More

Background: The serum copper (Cu) and ceruloplasmin (Cp) concentrations are common blood markers of copper metabolism. In altered physiological conditions, Cp can act as an acute phase reactant and its concentration may increase. Objective: To evaluate specific enzymatic activity of Cp as a potential indicator of Cu status and its correlation with serum Cu level. Methods: Serum Cu levels were estimated as p Read More