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Volume 18, Issue 1
  • ISSN: 2212-7968
  • E-ISSN: 1872-3136

Abstract

Background

Obesity is a serious chronic metabolic disease impairing health damaging many organs such as kidneys and muscles. Ovothiol-A (Ovo-A) has been found to keep the redox balance normal in sea urchins indicating its antioxidant characteristics.

Aim

This study aims to investigate the protective effects of Ovo-A on kidneys and muscles in obese rats.

Methods

studies were performed on lactate dehydrogenase (LDH) and creatine kinase (CK) with Ovo-A to compute their binding affinities. Obesity was induced by high-fat diet (HFD) for 4 weeks. Wistar rats were used in this study as 6 rats per group as control, HFD, Ovo-A (200 and 400 mg/Kg, p.o) groups.

Results

Docking results have revealed that Ovo-A has affinities to bind to LDH (-8.5 kcal/mol) and CK (-17.7 kcal/mol). Ovo-A reduced the levels of uric acid, urea, creatinine, LDH, CK, malondialdehyde (MDA), and nitric oxide (NO), while increasing the levels of glutathione (GSH), catalase (CAT), and glutathione-S-transferase (GST). Histopathological investigations have revealed that Ovo-A restored the renal and muscular structure.

Conclusion

The current study showed that Ovo-A has a protective effect on kidneys and muscles in obese rats. Ovo-A enhances renal and muscular functions by inhibiting LDH and CK activities and improving the antioxidant system. Ovo-A is more effective in the high dose.

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2024-09-12
2025-04-12

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Protective Role of Ovothiol-A against Muscle and Kidney Injuries in Obese Rats
Curr Chem Biol 18, 30 (2024); https://doi.org/10.2174/0122127968306623240830071012
/content/journals/ccb/10.2174/0122127968306623240830071012
/content/journals/ccb/10.2174/0122127968306623240830071012
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  • Article Type:     Research Article
Keyword(s): docking; high-fat diet; kidney; muscles; obesity; Ovothiol-A; oxidative stress

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