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Volume 18, Issue 1
  • ISSN: 2212-7968
  • E-ISSN: 1872-3136

Abstract

Background

Dandruff is not a disease in the traditional sense but rather a common scalp condition. It is usually a mild and harmless issue characterized by the flaking of dead skin cells from the scalp. Although it may not be a serious health concern, it can be a source of discomfort and embarrassment for some individuals. This study aimed to determine the antimicrobial potential and phytochemical analysis of peel.

Methods

The methanol extract of the peel was fractionated using column chromatography. The antimicrobial activity was assayed by and methods against the microbes that are dominantly found in dandruff sufferers . and .

Results

Aqueous fraction (Fr-V) and its hexane sub-fraction (Va) were most active with the maximum zone of Inhibition (ZOI) in a range of 36-42 mm at <0.05. Minimum Inhibitory Concentration (MIC) of sample fractions was in the range of 0.05-0.81 mg/mL. GC-MS analysis determined that methyl palmitate, 1-hexacosene, 1-heneicosyl formate, and 7-tetradecene in Fr-V, whereas methyl oleate and methyl stearate in Fr-Va, were the major phytoconstituents. Among all 1-Heneicosyl formate, 10-Heneicosene, and 1-Hexacosene showed the best docking score against Mflip1 lipase of ., -7.76, -7.43 and -7.34 kcal/mol.

Conclusion

Treatment for dandruff involves anti-dandruff shampoos containing active ingredients like pyrithione zinc, salicylic acid, ketoconazole, or selenium sulfide. People consider plant-based ingredients and natural remedies as alternatives to chemical ingredients for various purposes including skincare and haircare. Thereby, bioactive compounds identified in peel fractions could be used in anti-dandruff products.

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2024-08-07
2025-04-15

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/content/journals/ccb/10.2174/0122127968301442240802112802
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Evaluation of Antidandruff Potential of Punica Granatum Peel Fractions by In Vitro and In Silico Method
Curr Chem Biol 18, 13 (2024); https://doi.org/10.2174/0122127968301442240802112802
/content/journals/ccb/10.2174/0122127968301442240802112802
/content/journals/ccb/10.2174/0122127968301442240802112802
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  • Article Type:     Research Article
Keyword(s): Anti-dandruff; column chromatography; GC-MS; MIC; molecular docking; Punica granatum peel

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