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Volume 18, Issue 1
  • ISSN: 2212-7968
  • E-ISSN: 1872-3136

Abstract

Background

is frequently used in Mediterranean cuisine and is known for its possible medicinal properties. These properties are usually related to the presence of specific bioactive compounds present in the leaves of the artichoke. On the other hand, the root parts of the artichoke have not been subjected to extensive studies so far.

Objective

The main objective of this study was to conduct a chemical analysis of the root part of the hexane extract of subsp. and subsp. sylvestris, while exploring their antioxidant, anti-inflammatory, and hemolytic effects.

Methods

The chemical composition of the extracts of both species was analyzed using gas chromatography (GC) and gas chromatography coupled with mass spectroscopy (GC/MS). The antioxidant properties were evaluated using the DPPH radical scavenging method. The anti-inflammatory activity was evaluated through the protein denaturation method using diclofenac as a positive control. The hemolytic effect was examined on a suspension of erythrocytes in human blood.

Results

The main constituents of the hexane extract of and were aplotaxene (70.5% and 56.3%, respectively) and hexadecanoic acid (10.2% and 13.2%, respectively). The hexane extracts of and showed positive antioxidant activity with the DPPH test by comparing them with the BHT control. However, it should be noted that the extract of showed the best performance, with an IC of 4.3 μg/mL, while the extract of presented an IC of 5.6 μg/mL. The hexane extracts of and showed good anti-inflammatory activity with ICs of 17.3 μg/mL and 23.8 μg/mL compared to diclofenac (IC= 13.3 μg/mL), respectively. The toxicity assessment on human erythrocytes shows that both extracts of roots of and have a very low hemolysis rate (1.4% and 11.1%, respectively), even at high concentrations (2000 μg/mL).

Conclusion

The extracts obtained from hexane from the plants and , during the tests, revealed particularly promising antioxidant, anti-inflammatory, and hemolytic properties. These results offer an interesting perspective for the creation and development of new antioxidant and anti-inflammatory agents for the pharmaceutical and cosmetic industry.

© 2024 Bentham Science Publishers
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2024-08-22
2025-05-07

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Assessment of Chemical Composition and Investigation into the Antioxidant, Anti-inflammatory, and Hemolytic Properties of Hexane Extracts from Cynara cardunculus subsp. Cardunculus and Cynara cardunculus subsp. sylvestris
Curr Chem Biol 18, 46 (2024); https://doi.org/10.2174/0122127968309078240815053526
/content/journals/ccb/10.2174/0122127968309078240815053526
/content/journals/ccb/10.2174/0122127968309078240815053526
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  • Article Type:     Research Article
Keyword(s): anti-inflammatory activity; antioxidant activity; aplotaxene; egg albumin; hemolytic effect; Hexane extracts

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