Clinical Cancer Drugs - Volume 3, Issue 2, 2016

Background: Monoclonal antibodies have become attractive clinical anticancer drugs in the last 3 decades due to their targeting specificity and suitable pharmacokinetic properties. Mesothelin is a tumor-associated antigen with limited expression in normal tissues. It is frequently over-expressed on the cell membrane of a number of epithelial malignancies (e.g. mesothelioma, pancreatic, ovarian, lung, triple negative br Read More

Background: The Mesenchymal Epithelial Transition factor (c -Met, MET) is the tyrosine kinase cell surface receptor, and the only known high affinity ligand is hepatocyte growth factor (HGF). HGF/MET pathway is required for not only normal physiologic development, but also a wide variety of human malignancies. More and more pieces of evidence have been identified for the treatment of a variety of malignancies with c-Met/ Read More

Background: Conventional cancer therapies such as chemotherapy and radiotherapy are often characterised by lack of tumor specificity, increased resistance of tumors to drugs, failure to detect metastases and undesirable side effects. Several years back, William Coley’s pioneering work on the use of bacteria opened up the new field of cancer immunotherapy. The search for alternative and better strategies in cancer treatment Read More

Background: 5-Flurorouracil (5-FU) chemotherapy has been one of the extensively employed standard therapies for the treatment of colon cancer. Various molecular interventions and dose modulations in the form of adjuvant therapies has been exploited for better therapeutic efficacy and low adverse effects to improve overall survival rate in advanced colorectal cancer. Non-steroidal anti-inflammatory drugs (NSAIDs) have sho Read More

Background: Forskolin and Andrographolide are extensively used in many parts of Asia as traditional herbal medicines. Potato tumor bioassay has several advantages for pre-screening of antitumor molecules as compared to animal cell based bioassays. The present study was aimed to evaluate the antitumor potential, biochemical changes induced by the test compounds, and screening of their ability to interact with DN Read More

Background: A medical need exists for successfully treating patients afflicted with leukemia and especially those that relapse and ultimately become refractory to front line chemotherapies. Leukemia cases are particularly high within Hispanic populations where this disease is among the most frequently occurring cancer. A possible cause is somatic mutations in Janus tyrosine kinase (Jak3). Fourteen somatic mutations hav Read More

Background: A novel series of structurally divergent 1,5-diaryl-3-oxo- 1,4-pentadiene analogues 1-10 displayed marked cytotoxic potencies towards a number of human leukemia/lymphoma cells. Objective: To identify novel selective cytotoxic compounds that induce apoptosis. Methods: The Differential Nuclear Staining (DNS) screening protocol was utilized to measure the cytotoxicity of all experimental dienones on several c Read More