Clinical Cancer Drugs - Volume 3, Issue 1, 2016

Background: Recently, a number of genetic aberrations have been associated to prostate cancer, these can either cause prostate cancer directly by affecting mechanisms central to the survival of the prostatic cell or indirectly by making the cell more sensitive to endocrine or paracrine stimuli. The mature IGF-1 is one of the most common factors involved in the development of prostate cancer. Its mode of action is exerted thro Read More

Background: Prostate cancer (PCa) patients shall develop eventually incurable bone metastasis. Although advanced prostate cancer is the best known example of androgen- dependent neoplasia, PCa patients after an excellent clinical response to adrogen ablation therapies (medical or surgical castration) will ultimately become castration resistant (CRPC). Methods: Analysis of cell-cell interactions within the sites of osteo Read More

Background: The importance of epigenetics in cancer is well known. Since many epigenetic mechanisms are involved in cancer progression, they may represent a target for a new pharmacological approach. Prostate cancer is the most common malignancy in men. After failure of the androgen deprivation therapy, the recurrent disease is termed castration- resistant cancer (CRPC). Since CRPC remains an incurable dis Read More

Background: The serine/threonine protein kinase, Akt, plays a key role in the modulation of cellular proliferation, tumour growth and survival through phosphorylation of different downstream molecules. Here we review the recent progress in studying roles of the phosphatydil-4-5-bisphosphate-3-kinase (PI3K)/Akt/mTOR pathway in prostate cancer (PCa) therapy, mainly focusing on the effects of inhibitors targeting Read More

Background: Celastrol is a bioactive compound extracted from the root bark of “Thunder God Vine” (Tripterygium wilfordii, Hook F.) with anticancer activities against a broad spectrum of human cancer models. This article is aimed to review the mechanisms of action of celastrol against different cancers, and to discuss the limitations restricting it from clinical trials as well as the potential resolutions. Methods: MEDLINE database u Read More