Current Bioactive Compounds - Volume 3, Issue 1, 2007

Structural diversity is the most important fundamental in the modern drug discovery program. Every structural type, in principal, is capable of locking a particular disease mechanism. Everyday in various laboratories of the world, thousands of structurally diverse compounds are synthesized or isolated from natural sources. This structural diversity, if properly harnessed, can lead to breakthrough discoveries and improve, curr Read More

In this review we cover the structures, occurrence, biological activities and synthesis of all the spongianes and rearranged spongianes since their discovery in 1974. We have given special attention to structure revisions and biological properties of these polycyclic terpenoids of exclusive marine origin. However, an important part of the review describes the synthetic efforts in the field. Thus, this part has been subdivided into synt Read More

Podophyllotoxin is a naturally occurring lignan with important antineoplastic and antiviral properties and supported by detailed understanding of their mechanism of action, and facilitated by chemical manipulations that have amplified their bioactivity, the podophyllotoxin analogues have advanced to the forefront of several areas of therapeutic and developmental chemotherapy. Additive and synergistic laboratory interact Read More

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