Current Bioactive Compounds - Volume 3, Issue 2, 2007

Pentagalloylglucopyranose (PGG) is a natural product with widespread occurrence in the plant kingdom. It is present in various tissues of studied plants. PGG is synthesized in plants by covalently linking five galloyl groups to a glucose molecule through ester bonds. Two different linkages between the galloyl group and the anomeric center of the glucose core, carbon 1, are possible (Fig. 1). Both isomers were isolated from Read More

For management of pain, non-steroidal anti-inflammatory drugs (NSAIDs) play a major role. Use of NSAIDs is associated with toxicity, particularly in the gastrointestinal tract and kidney, whereas the use of COX-2 selective NSAIDs is associated with renal failure. Various approaches such as management of COX-1/COX-2 and 5-LOX/COX-2 inhibitors, use of natural products, formulation, drug modification and synthesis of new c Read More

The traditional use of Hypericum perforatum L. (St. John's wort, Clusiaceae) in Western medicine was well known even before the 1600s: St. John's extracts were used to relieve various types of nervous disease long before depression was recognized as a well described pathology. Today, random controlled trials clearly confirm the efficacy of this plant extract over placebo in the treatment of mild to moderately severe dep Read More

Amoebiasis, a disease caused by Entamoeba histolytica, remains a major health problem that afflicts several million people worldwide. Moreover, in recent years there has been a rise in the number of reports with amebic brain abscess as well as in developed countries the microorganisms that cause diarrheal diseases are a cause of concern because of their potential to be used as bioterrorist agent. Metronidazole, an antiamoe Read More

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