Current Bioactive Compounds - Volume 16, Issue 6, 2020

Background: Piperine, a bioactive alkaloid was a well-known component which was used traditionally to treat a variety of disorders. Objective: The present review is to discuss the modified piperine or piperic acid analogs or its derivatives to explore the potential of piperine. Piperine or piperic acid had potentials as antibacterial, antitumor, antioxidant, anti-inflammatory, antifungal, immunomodulatory and many more for drug Read More

The current review focuses on the comprehensive studies of platinum-based complexes that are known to exhibit anticancer properties. The research on metal-particle work has helped in treating sicknesses which plays an imperative part in therapeutic bioinorganic science. Understanding the biochemistry of the detoxification mechanism of metals can help in advancing as well as enhancing the anticancer pr Read More

Background: This review aims to highlight biotechnological techniques applied for the identification, isolation and propagation of mistletoe-derived bioactive compounds and the preclinical evaluation of their anticancer properties. Methods: We undertook a structured search of bibliographic databases to identify and evaluate the literature, regarding biotechnology of mistletoe and malignancy treatment. The selected articles Read More

Background: Naturally occurring chalcones afford diverse pharmacological activities such as anticancer, anti-malarial, anti-inflammatory, anti-tubercular, anti-hypertensive, anti-arrhythmic, antidiabetic, anti-angiogenic, anti-obesity, antiplatelet, anti-oxidant, hypolipidemic and anti-gout. They are frequently being used by the various researchers to design and develop new synthetic chalcones and many novel hybrid analo Read More

Background: Polyphenolics, a group of natural substances with a wide distribution in the plant kingdom present a great diversity of biological activities such as anti-oxidative, anti-inflammatory, anti-mutagenic, anti-carcinogenic, modulation of enzyme activity, prevention of CHD, etc. The objective of this review was to describe the relevant aspects of polyphenolics, reporting the different known groups, the probable mecha Read More

Background: Coumarins were reported to possess antimicrobial, antiinflammatory, antiplasmodial, antimalarial, and enzyme inhibitory properties. Furthermore, coumarins are a type of vitamin K antagonists. Coumarins had been first organized through perkin reaction; besides Knoevenagel condensation was mentioned as a critical synthetic approach for the synthesis of 3-substituted coumarins. Moreover, Pechmann, Refor Read More

Background: As coumarin derivatives are known to prevent and treat various diseases, they have attracted the attention of medicinal chemists. They have strong potential as drugs because their benzopyrone structure can interact noncovalently with numerous enzymes and receptors. Methods: The aim of this review was to summarize the most recently published literature on coumarin derivatives in terms of their antio Read More

Background: The primary objective of any pharmacotherapeutics approach entirely lies with the effectiveness of the rationally designed delivery system to effectually deliver the suitable drug at the appropriate concentration at the proper site. Phytosomes are most effective carrier for the possible enhancement of bioavailability, reduction in the clearance rate, providing higher dissolution, and amplification of solubility by se Read More

Background: Bacteria communicate by producing small signaling molecules to maintain threshold cell density. Quorum sensing inhibition is an effective and most potent approach for the prevention of cell to cell communication. Methods: In the present study, the methanol extract of Garcinia indica was tested for anti-quorum sensing activity using Chromobacterium violaceum as a biosensor. The extract inhibited viola Read More

Background: In the present study, chalcones were synthesized from 2-hydroxy-1- acetonaphthone and substituted aromatic aldehydes were synthesized by Claisen Schmidt condensation reaction using potassium hydroxide as a base. The synthesized chalcones were purified by recrystallization from ethanol and evaluated for antibacterial activity by well diffusion method. The antibacterial activity was evaluated a Read More

Background: Quinoxaline, a fused heterocycle of benzene and pyrazine rings are becoming recognized as a potent class of anti-cancer compounds, such as, in a wide array of pharmacological activities. Methods: We evaluate the three gallate quinoxalines (G-A1, G-A2, and G-A3) as c-Met kinase inhibitors using a docking study, in vitro anticancer potential measurements, antioxidant and bactericidal activities. Results: The docking Read More

Background: Pyrimidinones and its derivatives are present in many anti-cancer agents. It has been reported that these substances were proven to have significant activities against different types of human cancers. The incorporation of [1,2,3]-triazole, a nitrogen-rich unit not only increases the efficacy but also increases the lipophilicity of the drug molecule. As our research was to synthesize newer molecules of effective cytotoxi Read More

Background: Improvement in extract quality in terms of concentration of secondary metabolites and pharmacological activity has always been the need of the hour. In the present research, the target was to extract the selected medicinal herb using the ultrasound waves and to optimize the extraction conditions for the improvement in the quality of extract with respect to furan labdane diterpene (marrubiin) concentration an Read More

Background: Vector-borne diseases are quite prevalent globally and are one of the major causes of deaths due to infectious diseases. There is an availability of synthetic insecticides, however, their excessive and indiscriminate use have resulted in the emergence of resistant varieties of insects. Thus, a search for novel biopesticide has become inevitable. Methods: Rotenoids were isolated and identified from different part Read More