Skip to content
2000
Volume 16, Issue 6
  • ISSN: 1573-4072
  • E-ISSN: 1875-6646

Abstract

Background: In the present study, chalcones were synthesized from 2-hydroxy-1- acetonaphthone and substituted aromatic aldehydes were synthesized by Claisen Schmidt condensation reaction using potassium hydroxide as a base. The synthesized chalcones were purified by recrystallization from ethanol and evaluated for antibacterial activity by well diffusion method. The antibacterial activity was evaluated against Bacillus licheniformis, Bacillus species, Escherichia coli and Staphylococcus aureus using Ciprofloxacin as a standard. Methods: The target molecules were prepared by reacting 2-hydroxy-1-acetonaphthone and various substituted aromatic aldehyde in the presence of suitable condensing agents. The structure of synthesized compounds was confirmed on the basis of elemental analysis, IR, 1H NMR and 13C NMR spectral data. These synthesized compounds were also screened for antibacterial activity. Results: In the present study, free hydroxyl group in position 2 or 4 of aldehyde ring of synthesized chalcones appears to be a very important requirement in increasing the activity (2-5 and 8-13). When the hydroxyl group in position 4 is alkylated (14, 15), the chalcones become less active. When more complex substituent is present on the aldehyde ring (6, 7) there is a decrease in the activity. Conclusion: Newly synthesized chalcones (1-15) show good and moderate antibacterial activity. We believe that the new hydroxy substituted (in aldehyde ring) chalcones (2-5 and 8-13) reported in this work may provide an interesting insight for further optimization.

Loading

Article metrics loading...

/content/journals/cbc/10.2174/1573407215666190401202553
2020-08-01
2025-07-13
Loading full text...

Full text loading...

/content/journals/cbc/10.2174/1573407215666190401202553
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test