Current Bioactive Compounds - Volume 13, Issue 4, 2017

Background: Neoflavonoids comprise a group of compounds that have a C6-C3-C6 carbon skeleton and that naturally occur in higher plants from families Clusiaceae, Leguminosae, Rubiaceae, Passifloraceae, Asteraceae and Rutaceae. Objective: Neoflavonoids have drawn great interest lately due to their pharmacological and biochemical properties found in vitro and in vivo studies, which is attributed to the pattern of substituti Read More

Background: Despite being known for their antibacterial activity, the oxazolidines are molecules with wide pharmacological action and may act as anticonvulsants, anti-inflammatory and antineoplasic agents. However, such activities have been poorly explored and only two oxazolidinic derivatives hit the market until now. Therefore, this review covers the main biological activities of oxazolidines, indicating which of the cl Read More

Background: Dermaseptin-01 (DRS-01) is an antimicrobial peptide isolated from the skin secretions of frogs from Phyllomedusa genus with potential antileishmania properties. Considering that the innate immunological mechanisms underlying the production of reactive oxygen and nitrogen species is essential in controlling infection by microorganisms, the effects of DRS-01 on the immune response still remain unkn Read More

Background: Quantitative analysis of enzyme reactivity is a basic requirement for the development of precise diagnostic methods and drug discovery processes, and reduces the number of animal tests. Designed engineering proteins are preferred for developing effective synthesis methods for industrial uses. The specific affinity for an enzyme reaction can be analyzed in silico, but it is difficult to develop a general r Read More

Background: Coumarins, possesing antimicrobial activity are often used by the researchers to develop novel synthetic and semisynthetic coumarin based therapeutic agents. Molecular hybridization concept was used to design coumarin hybrid molecules. Synthesized molecules were evaluated for their invitro antibacterial activities. We designed Coumarin derivatives of diphenyl ether and oxadiazole. Most of the compounds sho Read More

Background: In vitro-in vivo correlation (IVIVC) is a quantitative and reliable relationship between in vitro drug release and in vivo absorption, which is desirable for rational development and optimization of sustained release formulations. The present work demonstrates development and application of IVIVC for 150 mg sustained release tablets of bupropion hydrochloride. Methods: Two sustained release prototype tablets Read More

Background: Anthocyanins are water-soluble photo-protective compounds which rapidly degrade in aqueous environments. Stability as well as skin permeation and UV protection are of concern in the development of sunscreen products from anthocyanins. An anthocyanin complex (AC) was developed and tested for its feasible applications as a sunscreen in in vitro. Methods: Two sources of anthocyanins used as the main co Read More

Objective: This study was accomplished to evaluate the in vitro antioxidant activity, in vivo antipyretic and the anti-inflammatory activities of the n-butanol extract of roots and aerial parts of Algerian Eryngium campestre L. Materials and Methods: The antioxidant properties were tested using DPPH radical scavenging and β- Carotene linoleic acid of various extracts from roots and aerial parts of E. campestre L., total phenolic a Read More

Background: The antibacterial, antifungal and antiparasitic activities of some novel benzosultams and benzosultones in vitro systems are tested. The antibacterial activity has been tested against gram negative bacterium Escherichia coli (E. coli) and gram positive Bacillus subtilis (B. subtilis). The antifungal activity has been tested against an opportunistic pathogenic fungal strain namely Pichia guilliermondii SNP3S. The antipar Read More

Background: Chromene, benzochromene and their derivatives have been studied extensively due to their biological and pharmacological activities. Benzochromene nucleus has been emerged as a promising and attractive scaffold in the development of potent antitumor agents. Objectives: Design a series of new 2-amino-4H-benzo[h]chromene derivatives and evaluated their antiproliferative activity against three human tum Read More