Investigation of In Vitro Antioxidant Activity and In Vivo Antipyretic and Anti-Inflammatory Activities of Algerian Eryngium campestre L.

Objective: This study was accomplished to evaluate the in vitro antioxidant activity, in vivo antipyretic and the anti-inflammatory activities of the n-butanol extract of roots and aerial parts of Algerian Eryngium campestre L. Materials and Methods: The antioxidant properties were tested using DPPH radical scavenging and β- Carotene linoleic acid of various extracts from roots and aerial parts of E. campestre L., total phenolic and flavonoid contents were also determined. Furthermore, the anti-inflammatory and antipyretic activities of the n-butanol extracts were investigated on female wistar rats at the dose levels of 250 and 500 mg/kg body weight, using the egg albumin induced oedema and brewer's yeast induced pyrexia method respectively. Results: n-butanol extract of aerial parts had considerably higher antiradical activity with IC50 value of 16.140 µg/ml, and a good anti-inflammatory activity comparable to the standard drug diclofenac. Also, the n-butanol extract of roots possessed a better antipyretic effect (at both dose 250 mg/kg and 500 mg/kg) compared to the n-butanol extract of aerial parts. Conclusion: These results suggested that Eryngium campestre L. could be used to treat various inflammatory diseases.