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Volume 21, Issue 2
  • ISSN: 1573-4072
  • E-ISSN: 1875-6646

Abstract

Background

Periodontal disease and dental caries are two oral illnesses that are significantly influenced by microorganisms, hence the usefulness of finding natural substances to inhibit them.

Objective

This study aimed to assess the Labill. leaf and fruit essential oils effect against , and to study their anticariogenic and antiperiodonto pathogenic activities.

Methods

These activities were evaluated according to the determination of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), anti-biofilm effects, and the impact on the adhesion to hydroxyapatite, a main component of the tooth.

Results

Both leaf and fruit essential oils showed strong antibacterial activity against anaerobic bacteria: (MIC of 0.012%) and (MIC of 0.025%). Anticarcinogenic activity also showed MIC values of 0.06% against and, 0.5% against , and appropriate antifungal activity against . It is interesting to note that both oils showed a significant inhibitory property to biofilm formation by the different studied species and significantly reduced the adhesion capacity of and to the hydroxyapatite surface at very low concentrations of 0.12 and 0.5% for and , respectively.

Conclusion

These results highlight the strong potential of essential oils as antimicrobial and antibiofilm agents, as well as their ability to inhibit bacterial adhesion, which is promising for the prevention of dental caries and plaque. This implies that may be a new alternative source of substances of medicinal interest that can be used in the pharmaceutical industry to produce antimicrobial agents against dental caries and oral infectious diseases.

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2024-04-02
2025-05-11

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/content/journals/cbc/10.2174/0115734072296932240319060406
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Eucalyptus globulus Labill. Essential Oil Effect on the Attachment of Oral Bacteria to Hydroxyapatite and Biofilm Formation
Curr. Bioact. Compd. 21, E020424228522 (2025); https://doi.org/10.2174/0115734072296932240319060406
/content/journals/cbc/10.2174/0115734072296932240319060406
/content/journals/cbc/10.2174/0115734072296932240319060406
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  • Article Type:     Research Article
Keyword(s): anticariogenic activity; biofilm; E. globulus; Essential oils; hydroxyapatite; oral pathogens

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