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Volume 21, Issue 2
  • ISSN: 1573-4072
  • E-ISSN: 1875-6646

Abstract

Objective

The present study aimed to investigate the chemical profile and evaluate the antibacterial and antibiotic-modulating activity of the methanolic extract and ethyl acetate of the stem bark of against standard and multiresistant strains.

Methods

The Minimum Inhibitory Concentration was determined by the microdilution method, and the modulating potential of the extracts on aminoglycoside and β-lactam antibiotics was evaluated.

Results

The classes of secondary metabolites identified from qualitative chemical prospecting were flavones, flavonols, xanthones, flavonones, flavonols, catechins and leucoanthocyanidins. The assays showed inhibition only for -producing extended-spectrum -lactamase, carbapenemase and ATCC 25922 with MICs of 256, 512 and 512 μg/mL, respectively. The extracts, when associated with gentamicin and amoxicillin, showed synergism against all standard and multiresistant strains, with the exception of carbapenemase and producing extended-spectrum -lactamase, respectively. When combined with amikacin, they also demonstrated synergism against multidrug-resistant strains; however, only the ethyl acetate extract had a synergistic effect against ATCC 25922. The association of penicillin with methanolic extract showed synergism only for producing extended-spectrum -lactamase and S. aureus ATCC 29213, while the ethyl acetate extracts demonstrated synergism against and producing extended-spectrum lactamase.

Conclusion

It was found that extracts have antibacterial potential against gram-negative bacteria. However, the need for additional research using specific methods against bacteria carrying different resistance mechanisms, especially gram-positive ones, is highlighted, with the aim of elucidating their mechanism of action.

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/content/journals/cbc/10.2174/0115734072297726240430040317
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Chemical Profile with Antibacterial and Modulatory Activity of Extracts from the Stem Bark of Cnidoscolus quercifolius Pohl.
Curr. Bioact. Compd. 21, E130524229907 (2025); https://doi.org/10.2174/0115734072297726240430040317
/content/journals/cbc/10.2174/0115734072297726240430040317
/content/journals/cbc/10.2174/0115734072297726240430040317
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  • Article Type:     Research Article
Keyword(s): Antibacterial activity; Cnidoscolus quercifolius; favela; MIC; modulatory activity; phytochemistry

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