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Volume 20, Issue 10
  • ISSN: 1573-4072
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Abstract

Aim

The present study investigated the development of kidney stone formation in animal models involving renal tubular stone formation by ethylene glycol and COX-2 selective inhibitor-induced urolithiasis along with the diuretic potentiality by Lipschitz teston Wistar rats.

Background

() R. Br. played a prominent role in various ancient traditional systems of medications and possessed various pharmacological applications. Since the last few decades, urolithiasis has been a major constraint in both livestock and human health. Celecoxib administration increased urinary enzyme excretion but did not affect oxalate or citrate excretion in a urolithiasis model.

Objective

This research provides a comprehensive account of the ethnobotanical use of as an antiurolithiatic and diuretic agent in animal models.

Methods

The plant material was dried, pulverized into a dry powder, extracted with ethanol, and analyzed for the presence of various secondary metabolites. The anti-urolithic effect of ethanolic extract of roots in albino rats was investigated using ethylene glycol (0.75%) and COX -2 selective inhibitor models.

Results

The experimental data showed the significant effect of root extract (HIEE) as anti-urolithiasis by the prevention of kidney stone formation, also by decreasing crystal nucleation, growth inhibition, decreased aggregation, and crystal retention within the renal tubules. The effect of HIEE supplementation prevents the impairment of renal stone formation, which was also confirmed by the histological findings. HIEE also acts as a potent diuretic, which supports the study.

Conclusion

The results indicated that HIEE was effective against experimentally induced urolithiasis, and it also acts as a potent diuretic in treated animals. So, it needs to perform future research on medicinal plants, including mechanistic and human studies for urolithiasis.

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2024-12-01
2024-11-22

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/content/journals/cbc/10.2174/0115734072286989240124112311
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Anti Urolithiatic and Diuretic Potentiality of Hemidesmus indicus R. Br.
Current Bioactive Compounds 20, E020224226665 (2024); https://doi.org/10.2174/0115734072286989240124112311
/content/journals/cbc/10.2174/0115734072286989240124112311
/content/journals/cbc/10.2174/0115734072286989240124112311
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  • Article Type:     Research Article
Keyword(s): diuretic; H. indicus; kidney stone; medicinal plants; phytochemicals; urolithiasis

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