Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Bioactive Compounds
  4. Volume 20, Issue 10
  5. Article
Volume 20, Issue 10
  • ISSN: 1573-4072
  • E-ISSN:

Abstract

Background

In the immunocompromised population, are the most aetiologic agents causing severe nosocomial fungal infections. , irrespective of being commensals in the human microbiome, are the fourth most prevalent source of potentially fatal yeast infections. Monotherapy is frequently employed to treat invasive fungal infections, but sometimes, patients do not favor the monotherapy treatment regime. It may be because of the reduced susceptibility of the pathogen toward traditional antimycotic drugs. Antimycotic drug combination therapy could be a better choice in such specific circumstances. In our study, we evaluated the interactions of fluconazole with diphenyl diselenide.

Methods

The antimycotic susceptibilities of for fluconazole and diphenyl diselenide were determined by broth microdilution assay, and the interactions of fluconazole with diphenyl diselenide were studied by using disc diffusion assay and chequerboard assay. The nature of the interactions was assessed by calculating the fractional inhibitory concentration index (FICI). The interactions were also analyzed by the response surface approach.

Results

The minimum inhibitory concentrations (MICs) for fluconazole and diphenyl diselenide as determined by the broth microdilution assay against were 4 μg/ml-512 μg/ml and 1 μg/ml-32 μg/ml, respectively. The FICI values varied from 0.375 to 2.

Conclusion

Our finding demonstrated that there is no antagonism interaction between fluconazole and diphenyl diselenide in . Thus, this innovative combination should be explored in the future.

© 2024 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cbc/10.2174/0115734072282896240115111712
2024-12-01
2024-11-26

  • From This Site

    /content/journals/cbc/10.2174/0115734072282896240115111712
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. HoeniglM. SeidelD. SpruteR. CunhaC. OliverioM. GoldmanG.H. IbrahimA.S. CarvalhoA. COVID-19-associated fungal infections.Nat. Microbiol.2022781127114010.1038/s41564‑022‑01172‑2 35918423
     [Google Scholar]
  2. MinaS. YaakoubH. AnnweilerC. DubéeV. PaponN. COVID-19 and fungal infections: A double debacle.Microbes Infect.202224810503910.1016/j.micinf.2022.105039 36030024
     [Google Scholar]
  3. ChiurloM. MastrangeloA. RipaM. ScarpelliniP. Invasive fungal infections in patients with COVID-19: A review on pathogenesis, epidemiology, clinical features, treatment, and outcomes.New Microbiol.20214427183 34240742
     [Google Scholar]
  4. KhalifaH.O. MajimaH. WatanabeA. KameiK. In vitro characterization of twenty-one antifungal combinations against echinocandin-resistant and -susceptible candida glabrata.J. Fungus20217
     [Google Scholar]
  5. WagnerH. Ulrich-MerzenichG. Synergy research: Approaching a new generation of phytopharmaceuticals.Phytomedicine2009162-39711010.1016/j.phymed.2008.12.018 19211237
     [Google Scholar]
  6. PoesterV.R. MatteiA.S. MendesJ.F. KlafkeG.B. RamisI.B. SanchoteneK.O. XavierM.O. Antifungal activity of diphenyl diselenide alone and in combination with itraconazole against Sporothrix brasiliensis.Med. Mycol.201957332833110.1093/mmy/myy044 29924365
     [Google Scholar]
  7. Reference Method for Broth Dilution Antifungal susceptibility testing of yeast.Clin Lab Stand Inst.201232123
     [Google Scholar]
  8. SchwarzP. BidaudA.L. DannaouiE. In vitro synergy of isavuconazole in combination with colistin against Candida auris.Sci. Rep.20201012144810.1038/s41598‑020‑78588‑5 33293607
     [Google Scholar]
  9. DahiyaS. SharmaN. PuniaA. ChoudharyP. GuliaP. ParmarV.S. ChhillarA.K. Antimycotic drugs and their mechanisms of resistance to candida species.Curr. Drug Targets202223211612510.2174/1389450122666210719124143 34551694
     [Google Scholar]
  10. AllenD. WilsonD. DrewR. PerfectJ. Azole antifungals: 35 years of invasive fungal infection management.Expert Rev. Anti Infect. Ther.201513678779810.1586/14787210.2015.1032939 25843556
     [Google Scholar]
  11. JohnsonM.D. PerfectJ.R. Combination antifungal therapy: What can and should we expect?Bone Marrow Transplant.200740429730610.1038/sj.bmt.1705687 17563740
     [Google Scholar]
  12. Di VeroliG.Y. FornariC. WangD. MollardS. BramhallJ.L. RichardsF.M. JodrellD.I. Combenefit: An interactive platform for the analysis and visualization of drug combinations.Bioinformatics201632182866286810.1093/bioinformatics/btw230 27153664
     [Google Scholar]
  13. GreckaK. SzwedaP. Synergistic effects of propolis combined with 2-phenoxyethanol and antipyretics on the growth of staphylococcus aureus.Pharmaceutics202113221510.3390/pharmaceutics13020215 33557393
     [Google Scholar]
  14. HeardK.L. HughesS. MughalN. MooreL.S.P. COVID-19 and fungal superinfection; The Lancet.EnglandMicrobe2020Vol. 1e107
     [Google Scholar]
  15. SanguinettiM. PosteraroB. Lass-FlörlC. Antifungal drug resistance among Candida species: Mechanisms and clinical impact.Mycoses201558S2Suppl. 221310.1111/myc.12330 26033251
     [Google Scholar]
  16. Garcia-RubioR. Cuenca-EstrellaM. MelladoE. Triazole resistance in aspergillus species: An emerging problem.Drugs201777659961310.1007/s40265‑017‑0714‑4 28236169
     [Google Scholar]
  17. Moreira RosaR. de OliveiraR.B. SaffiJ. BragaA.L. RoeslerR. Dal-PizzolF. Fonseca MoreiraJ.C. BrendelM. Pêgas HenriquesJ.A. Pro-oxidant action of diphenyl diselenide in the yeast Saccharomyces cerevisiae exposed to ROS-generating conditions.Life Sci.200577192398241110.1016/j.lfs.2005.01.029 15932762
     [Google Scholar]
  18. NogueiraCW QuinhonesEB JungEAC ZeniG RochaJBT Anti-inflammatory and antinociceptive activity of diphenyl diselenide.Inflamm Res Off J Eur Histamine Res Soc2003522566310.1007/s000110300001
     [Google Scholar]
  19. BritoV.B. RochaJ.B.T. FolmerV. ErthalF. Diphenyl diselenide and diphenyl ditelluride increase the latency for 4-aminopyridine-induced chemical seizure and prevent death in mice.Acta Biochim. Pol.200956112513410.18388/abp.2009_2524 19238257
     [Google Scholar]
  20. PrigolM. LucheseC. NogueiraC.W. Antioxidant effect of diphenyl diselenide on oxidative stress caused by acute physical exercise in skeletal muscle and lungs of mice.Cell Biochem. Funct.200927421622210.1002/cbf.1559 19382129
     [Google Scholar]
  21. WilhelmE.A. JesseC.R. LeiteM.R. NogueiraC.W. Studies on preventive effects of diphenyl diselenide on acetaminophen-induced hepatotoxicity in rats.Pathophysiology2009161313710.1016/j.pathophys.2008.12.002 19162454
     [Google Scholar]
  22. De BemA.F. PortellaR.L. FarinaM. PerottoniJ. PaixãoM.W. NogueiraC.W. RochaJ.B.T. Low toxicity of diphenyl diselenide in rabbits: A long-term study.Basic Clin. Pharmacol. Toxicol.20071011475510.1111/j.1742‑7843.2007.00073.x 17577316
     [Google Scholar]
  23. de BemA.F. de Lima PortellaR. PerottoniJ. BeckerE. BohrerD. PaixãoM.W. NogueiraC.W. ZeniG. RochaJ.B.T. Changes in biochemical parameters in rabbits blood after oral exposure to diphenyl diselenide for long periods.Chem. Biol. Interact.2006162111010.1016/j.cbi.2006.04.005 16737689
     [Google Scholar]
  24. NogueiraC.W. RochaJ.B.T. Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds.Arch. Toxicol.201185111313135910.1007/s00204‑011‑0720‑3 21720966
     [Google Scholar]
  25. NogueiraC.W. MeottiF.C. CurteE. PilissãoC. ZeniG. RochaJ.B.T. Investigations into the potential neurotoxicity induced by diselenides in mice and rats.Toxicology20031831-3293710.1016/S0300‑483X(02)00423‑7 12504340
     [Google Scholar]
  26. LoW.H. DengF.S. ChangC.J. LinC.H. Synergistic antifungal activity of chitosan with fluconazole against candida albicans, candida tropicalis, and fluconazole-resistant strains.Molecules20202521511410.3390/molecules25215114 33153228
     [Google Scholar]
  27. ZhuB. LiZ. YinH. HuJ. XueY. ZhangG. ZhengX. ChenW. HuX. Synergistic antibiofilm effects of pseudolaric acid a combined with fluconazole against candida albicans via inhibition of adhesion and yeast-to-hypha transition.Microbiol. Spectr.2022102e01478e2110.1128/spectrum.01478‑21 35297651
     [Google Scholar]
  28. HaoW. WangY. XiY. YangZ. ZhangH. GeX. Activity of chlorhexidine acetate in combination with fluconazole against suspensions and biofilms of Candida auris.J. Infect. Chemother.2022281293410.1016/j.jiac.2021.09.018 34674944
     [Google Scholar]
  29. LiuS. HouY. ChenX. GaoY. LiH. SunS. Combination of fluconazole with non-antifungal agents: A promising approach to cope with resistant Candida albicans infections and insight into new antifungal agent discovery.Int. J. Antimicrob. Agents2014435395402https://www.sciencedirect.com/science/article/pii/S092485791400002810.1016/j.ijantimicag.2013.12.009 24503221
     [Google Scholar]
  30. GaoY. ZhangZ. LunZ. GongL. XuA. LiX. Synergistic effects of fluconazole combined with doxycycline against dual-species cultures of candida albicans and staphylococcus epidermidis and the mechanisms of action.Microb. Drug Resist.202228552553510.1089/mdr.2021.0301 35363560
     [Google Scholar]
  31. VenturiniT.P. ChassotF. LoretoÉ.S. KellerJ.T. AzevedoM.I. ZeniG. SanturioJ.M. AlvesS.H. Antifungal activities of diphenyl diselenide and ebselen alone and in combination with antifungal agents against Fusarium spp.Med. Mycol.201654555055510.1093/mmy/myv120 26773133
     [Google Scholar]
  32. Felli KubiçaT. Bedin DenardiL. Silva de LoretoÉ. ZeniG. WeiblenC. OliveiraV. Morais SanturioJ. Hartz AlvesS. In vitro activity of diphenyl diselenide and ebselen alone and in combination with antifungal agents against Trichosporon asahii.Mycoses201962542843310.1111/myc.12906 30784136
     [Google Scholar]
  33. MeloA.M. PoesterV.R. TrapagaM. NogueiraC.W. ZeniG. MartinezM. SassG. StevensD.A. XavierM.O. Diphenyl diselenide and its interaction with antifungals against Aspergillus spp.Med. Mycol.202159652853610.1093/mmy/myaa072 32844203
     [Google Scholar]
  34. RossatoL. LoretoE.S. VenturiniT.P. de AzevedoM.I. Al-HatmiA.M.S. SanturioJ.M. AlvesS.H. In vitro combination between antifungals and diphenyl diselenide against Cryptococcus species.Mycoses201962650851210.1111/myc.12905 30776159
     [Google Scholar]
/content/journals/cbc/10.2174/0115734072282896240115111712
Loading
In-vitro Interactions between Fluconazole and Diphenyl Diselenide against Various Candida Species
Current Bioactive Compounds 20, E310124226578 (2024); https://doi.org/10.2174/0115734072282896240115111712
/content/journals/cbc/10.2174/0115734072282896240115111712
/content/journals/cbc/10.2174/0115734072282896240115111712
Loading

Data & Media loading...


  • Article Type:     Research Article
Keyword(s): Candida species; combination therapy; diphenyl diselenide; FICI; fluconazole; response surface approach

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test