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Volume 20, Issue 10
  • ISSN: 1573-4072
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Abstract

Background

A new series of 2-(2-(substituted aldehyde)hydrazinyl)-4-(2-chlorophenyl)-1-methyl-6-oxo-1,6-dihydropyrimidine-5-carbonitrile analogs (1–19) was prepared by using the Biginelli reaction.

Methods

TLC was employed to ensure the progress and confirmation of the reactions. Silica gel G was employed as the stationary phase, and mobile phases such as chloroform: toluene and acetone: n-hexane were used for the synthesized compounds. NMR.MS, IR, CHN spectral techniques used for the characterization of synthesized compound.

Results

The prepared derivatives were evaluated for antimicrobial activity against various bacteria and fungi using the tube dilution technique. Notably, compounds T1, T6, and T16, displayed significant antibacterial activity, surpassing the standard drug Ampicillin. In the antifungal category, compounds T1, T2, and T13, were very much effective against both fungal strains as well as . Furthermore, compounds T6, T8, T12, and T14 demonstrated remarkable antioxidant properties, because of their low IC values in the DPPH assay. In the realm of anticancer activity, T9 outperformed the standard drug Adriamycin in terms of its effectiveness against human lung cancer cells (A-549) with a GI value of less than 10 according to the SRB assay. In addition, the antidiabetic assessment highlighted the excellent performance of compounds T8, T12, and T15, with low IC values, when tested for their inhibition of α-amylase enzyme activity.

Conclusions

The synthesized derivatives demonstrated strong antimicrobial, antioxidant, anticancer, and antidiabetic properties when assessed using specific methods and compared to established drugs. Notably, compounds T1, T6, and T13, T12 and T9 exhibited even higher activity levels than the standard medications. The presence of electron-releasing groups in the synthesized compounds enhanced their antibacterial and antioxidant effects, particularly against . On the other hand, electron-withdrawing groups improved their anticancer and antidiabetic properties.

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2024-10-09

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A Convenient and Practical Synthesis of Novel Pyrimidine Derivatives and its Therapeutic Potential
Current Bioactive Compounds 20, E220224227309 (2024); https://doi.org/10.2174/0115734072282575240213091008
/content/journals/cbc/10.2174/0115734072282575240213091008
/content/journals/cbc/10.2174/0115734072282575240213091008
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  • Article Type: Research Article
Keyword(s): anticancer activity and antidiabetic activity; antimicrobial; antioxidant; Pyrimidine derivatives; silica gel; tube dilution technique

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