Current Analytical Chemistry - Volume 4, Issue 2, 2008

Anthocyanins are a class of polyphenols responsible for the orange, red, purple and blue colors of many fruits, vegetables, grains, flowers and other plants. Consumption of anthocyanins has been linked as protective agents against many chronic diseases and possesses strong antioxidant properties leading to a variety of health benefits. In this review, we examine the advances in the chemical profiling of natural anthocyan Read More

Accelerator mass spectrometry (AMS) has emerged as an important analytical tool in biomedical and pharmaceutical research. Its sensitivity (up to attomole, 10-18 levels), precision, low sample requirements and the ability to trace a biomarker over a prolonged period of time are valuable attributes. Metabolomic, kinetic, toxicokinetic and dosimetric studies of various chemical molecules, at environmental exposure levels a Read More

Hydromorphone, a semi-synthetic derivative of morphine, is being used in the treatment of moderate to severe cancer-related and post-operative pain. It is also one of the most commonly prescribed drug that is often abused. Hence, its detection in biological samples and tissues is important for legal and therapeutic reasons. The purpose of this review is to give a brief description of the various non-chromatographic and chro Read More

Immobilised metal affinity chromatography (IMAC) has become an established purification procedure for the selective isolation of proteins, peptides and post-translationally modified peptides, using a wide range of metal ions, including Cu(II), Fe(III) and Ga(III). Recently, the potential of interfacing capillary IMAC with mass spectrometry has been explored. This article reviews the development and use of IMAC in protein/peptide anal Read More

The electrochemical reduction of 4-{[(1E)-(2-hydroxynaphthyl)methylidene]amino}-1,5-dimethyl-2-phenyl- 2,3-dihydro-1H-pyrazol-3-one (NAP) was studied by using cyclic voltammetry in acetonitrile media at a glassy carbon (GC) and modified GC electrodes. The GC electrodes were grafted by electrochemical reduction of diazonium salts of various organic molecules. GC surfaces modified with anthraquinone, p-nitrophenyl, p-a Read More

A review is presented on recent applications of experimental design and optimization techniques for the analysis of compounds of food, biomedical, toxicological and environmental concern. The main features and the significant advantages of chemometric approaches are discussed. Examples related to the determination of substances like xenobiotics, naturally occurring compounds and metals using different analytical techniq Read More

A new method was developed for the determination of lomefloxacin by using flow-injection chemiluminescence( CL) based on the reaction of Ce(IV)-sodium thiosulfate-lomefloxacin-sulfuric acid system. The CL conditions were investigated and optimized. The CL intensity was correlated linearly with concentration of lomefloxacin in the range of 1.0x10-5∼6.0x10-2 g L-1. The determination limit (3σ) is 3x10-6 g L-1. The rel Read More

This review updates knowledge on pressurized liquid extraction (PLE), a sample preparation technique that is increasingly used to extract moderately volatile and non-volatile organic pollutants from solid and semi-solid environmental matrices. In environmental analyses, therefore, it is mainly been used to analyse soils and sewage sludge, though it has also been used, albeit to a lesser extent, to analyse air samples. As i Read More