Current Analytical Chemistry - Volume 18, Issue 10, 2022

Timely and accurate evaluation of clinical parameters associated with endothelial dysfunction is critical in diagnosing and treating atherosclerosis, which represents a severe health problem, accounting for at least 30% of deaths globally. A critical early event in the pathogenesis of atherosclerosis is the oxidative modification of low-density lipoprotein (LDL). Oxidized LDL (OxLDL) represents numerous changes in lipid Read More

Chirality seems to be a pivotal technique in the field of science. Research teams are quite well versed in empirical separation, however, at the same time, they are clueless about the evolution of chiral separation. As per the guidelines of the United States Food and Drug Administration (US FDA), chiral drugs must be unraveled before they are sold to the public. Stereogenic separation has gained prominence during the last 10 dec Read More

Background: The effluent release containing heavy metals, such as Cd (II) ions, poses drastic risks to both the natural environment and human health. In this research, a novel nano sorbent from the pyridine derivative was prepared for dispersive solid-phase extraction of Cd (II) ions. Methods: Graphene oxide (GrO) was chemically modified by a 2-aminopyridine group (2Ap) through a multistep procedure. The effect of Read More

Background: In this study, trace copper plays an important role in plant growth and is a biological component of various enzymes involved in both photosynthesis and plant respiration. Objective: Electrochemical voltammetric bioassay of trace copper ion was detected using photo-sensing diode circuits (PSD) with working sensors for ppb levels trace detection in agricultural water by stripping and cyclic voltammetry. Results: Opti Read More

Background: Cymbopogon khasianus is a widely used industrial and pharmacologically important aromatic grass species. Objective: The present investigation was designed to study and compare the elemicin rich Cymbopogon khasianus essential oil (EREO), its pharmacological effects and genotoxicity with pure compound elemicin. Materials and Methods: Chemical composition identification was performed using GC/MS and Read More

Background: The affinity of a drug to the identified target (protein/enzyme) is a critical characteristic in the development of a novel drug. Fluoroquinolone derivatives with a carboxylic group change have improved antimicrobial and anticancer activity while maintaining antibacterial activity similar to parent drugs. Aim: In this paper, the rationale upon which synthesis of the new compounds is based, evaluation of thei Read More

Aim: To develop a hot stage microscopy-based method for the determination of particle size in reverse engineering and establishment of a platform technology employing carvedilol as a model drug. It was hypothesized that reverse engineering using thermal methods would suggest a logical path in decoding the innovator’s formulation to develop an efficient generic product and preconize the morphology of an active pharmaceuti Read More

Background: Zinc oxide nanoparticles (ZnO-NPs) have been shown to exert a non-negligible impact on the environment. Objective: Kaolin and humic acid were used in the aqueous environment to study their effects on the removal of ZnO-NPs. Methods: In this work, polyaluminum ferric chloride (PAFC)/cationic polyacrylamide (CPAM) coagulants were used together with kaolin and humic acid to study their effects on the r Read More