Current Analytical Chemistry - Volume 12, Issue 6, 2016

Prussian blue (PB) is one of the most commonly used electrochemical mediators for analytical applications during the last decades. Its redox properties of electro-catalyzing hydrogen peroxide qualify it to be used in construction of various sensors for environmental, clinical and food analysis. In this review, the significant characteristic of PB was extensively discussed. Several methods for synthesizing Prussian blue na Read More

Background & Objective: The presence of Lewis acid sites on the metal oxides is responsible for a problematic elution of Lewis bases from these stationary phases due to the ligand exchange. The interactions are quite strong and the kinetics is relatively slow which is chromatographically undesirable. On the other hand, the interactions based on ligand-exchange could be employed in the solid-phase extraction. We newly t Read More

Background: Supercritical Fluid Chromatography (SFC) is an eco-friendly and sensitive method for the determination of various polar and non-polar analytes. SFC is offering advantage of low solvent consumption. The aim of this paper is to describe a novel SFC method for determination of montelukast in formulation and exploring the possibility of the method for the degradation study of montelukast. Methods: Methanol wa Read More

Background: Quantitative structure-activity relationship studies of long chain arylpiperazines demonstrated that 5-HT1A affinity is influenced by the nature of the aryl group at N1 of the piperazine ring and the length of the alkyl chain at N4 position linked to terminal amide or imide part, but still the function of terminal amide/imide moieties is less clear. Objective: The aim of the study is building analytical models useful in predicti Read More

Background: Tons of pharmaceutical compounds are used every year around the world in human and veterinary medicine, and these can reach wastewater treatment plants by metabolic excretion and/or improper disposal. Some compounds are not completely eliminated during the wastewater purification processes and are introduced into the environment through a variety of sources and pathways. Pharmaceutical Read More

MC-ICP-MS analysis is conducted on seven Han dynasty bronze artifacts from Liangshan Yi Autonomous Prefecture Museum, Sichuan Province, Southwest China. The lead isotope ratios conform to the characteristics of the common lead. The lead ore sources are mainly located in Mengzi-Gejiu and Qiaojia-Huize area, Yunnan Province. Some lead ore was from Geochemical Province of Southern China. A further study shows Read More

Background: Mixed anxiety depressive disorder is commonly treated with a mixture of an antidepressant and a benzodiazepine drug. Quality control to ensure that these products comply with the specifications is required. To improve the quality control of pharmaceutical products throughout the world, accessible analytical methods are needed. Objective: The aim was to develop fast, simple, cheap, accurate and e Read More

Cyclovirobuxine D is an active steroid alkaloid distributed in Buxus microphylla and applied in therapeutic practice of cardiovascular disease. This study describes the development of a new CRM, which includes the homogeneity assessment, stability assessment, purity determination, and uncertainty evaluation. DSC method was applied to the value assignment of cyclovirobuxine D for the first time. The certified purity valu Read More

Background: Hair provides important information that helps medicine with an early diagnosis of physiological disorders associated with metabolic alterations of essential and toxic elements. However, some metals are present in the hair sample in very low concentrations for some analytical techniques, such as flame atomic absorption spectrometry. This work aims to develop an on-line pre-concentration system for copper d Read More

Background: Epinephrine (EP), ascorbic acid (AA) and tyrosine (TY) usually coexist together in human blood and are considered as important molecules for physiological processes in human metabolism. Thus, to determine these compounds in biological fluids, we need to develop sensitive, simple and rapid methods. Method: The simultaneous spectrophotometric determination of AA, EP and TY, at pH=7.0 using multivariate Read More

Background: Solifenacin is used for the treatment of overactive bladder. At present, a number of separation and determination techniques, including high-performance liquid chromatography, Liquid chromatography–tandem mass spectrometry and spectrophotometric techniques have been used for the analysis of solifenacin in different samples. Objective: In the present work, for the first time, a Hollow fiber based liqui Read More

Background: Hot corrosion is a phenomenon seen in gas turbines using residual fuel oils, which contains vanadium. Austenitic stainless steels are ones of the most used materials in components and devices of boilers, gas turbines and furnaces burning contaminated fuel oil. The materials selection is made in great extend due to a good corrosion resistance and low cost. Some works have been done in order to determine t Read More

A sequential injection analysis (SIA) was developed for the determination of ferrous ion (Fe(II)). The detection method was based on monitoring of surface plasmon resonance at 446 nm of the product obtained by on-line reaction of silver nanoclusters (AgNCs) with Fe(II). The experimental parameters affecting the sensitivity were investigated, including sequence order of operation, volume of sample and reagent zones, flo Read More

Background: Microbiological assay is the gold-standard method for analyzing antibiotics, since it ensures the success of antimicrobial therapy. However, this method may be time-consuming and it remains almost unaltered since it was first developed. Here, we present the design space of a rapid microplate bioassay for bacitracin. Methods: Triphenyltetrazolium chloride was used in the bioassay to provide faster response. Fa Read More

Background: Nitrite is a carcinogenic compound and can be found in water, soil, and food products. Determining the presence of nitrite has become very important in monitoring water quality and food safety. Methods: A highly sensitive optical chemical sensor based on sol-gel film for trace amounts of nitrite was developed. The Xylene cyanol FF dye doped organic-inorganic silica hybrid film was obtained by copolymeri Read More

Background: The biosensors are analytical devices combining a bioreceptor and a physicochemical transducer to translate the signal resulting from the interaction of the analyte with the biological element into an electrical reading. The technological attractiveness of the biosensors resides in their high sensitivity, continuous measuring capabilities, low cost, and precision. An important and promising area of biosensors applicati Read More

A sensitive, accurate and simple method for the simultaneous preconcentration of Cu(II), Ni(II), Cd(II), Mn(II), Cr(III) and Pb(II) in milk samples has been reported in this study. Target metal ions were determined by flame atomic absorption spectrometry (FAAS) after preconcentration on Aspergillus niger (A. niger) loaded on TiO2 nanoparticles. The dead biomass of A. niger was first loaded on TiO2 nanoparticles and bioad Read More