Anti-Infective Agents - Volume 21, Issue 2, 2023

Antibiotics play an essential role in antimicrobial therapy. Among all the medications in children, the most commonly prescribed therapy is antibiotics and is currently the indispensable means to cure transmissible diseases. Several categories of antibiotics have been introduced into clinical practice to treat microbial infections. Reducing the unnecessary use of antibiotics is a global need and priority. This article aims t Read More

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a Gram-positive strain whose resistance against existing antibiotics is a significant concern for researchers across the globe. Gram-positive infections, particularly methicillin-resistant Staphylococcus aureus spreading among S. aureus isolates, increased exponentially from 29% in 2009 to 47% in 2014. Literature reviews revealed that about 13-74% of S Read More

Background: The first case of COVID-19 emerged in China in 2019 and spread rapidly worldwide. Therefore, all researchers worldwide sought ways to treat and prevent the disease. Since the production of vaccines and new drugs is time-consuming, a good way is to look at existing drugs to find new effects. Objective: Due to the pathogenic mechanism of COVID-19, most of its symptoms, including anosmia, ageusia, and cytokine Read More

Background: Flavonoids are low molecular weight class secondary metabolites found to be present throughout the plant kingdom. Structurally, flavonoid class phytochemicals consist of C6-C3-C6 chemical structures with different substitution patterns and have drug-like nature. Morelloflavone is a biflavonoid class phytochemical found to be present abundantly in the Garcinia genus. Morelloflavone has been inves Read More

Introduction: Since sepsis is a major global health problem, a rapid and correct diagnosis and the initiation of therapy are essential patient consequences. This study aimed to assess the serum levels of calprotectin and a more widely used sepsis biomarker in the patients with bacterial sepsis (BS). Methods: Subjects were classified into BS group with the patients who met the sepsis criteria at the beginning of the study a Read More

Background: Hydroxychloroquine (HCQ) may be an effective, safe, and affordable treatment for Covid-19 that can be used in selected patients. However, more evidence on its association when it is used in different stages of the disease with clinical outcomes is required. This observational study investigates the association between treatment with HCQ and mortality in patients with Covid-19. Methods: The data from 6217 pa Read More

Background: Treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in immuno-compromised patients with complete B cell depletion can be really challenging due to the lack of seroconversion and long-lasting disease. Case Report: We describe a case of long-lasting coronavirus disease (COVID-19) in a female patient with rheumatoid arthritis who was treated with rituximab and continued Read More

Background: Recently, plant-based medications have been considered promising. Scrophularia has been demonstrated to have antibacterial, antifungal, antiparasitic, anticancer, and antiinflammatory effects; however, no evidence of its antiviral potency is available. Objective: This study aimed to evaluate whether the aqueous extract of Scrophularia variegata has antiviral activity against rotavirus as the leading cause of Read More

Background: Essential oil of M. vulgare is an important natural source that can be useful in controlling the infection of tomatoes and larvicides. Introduction: This work aimed to determine seasonal variations (winter, spring and summer) of the composition of M. vulgare essential oil and fungicidal and larvicidal potential of this oil. Methods: Essential oils were obtained by a Clevenger-type apparatus and analyzed by using Read More