Anti-Infective Agents - Volume 15, Issue 2, 2017

TB is one of the major infectious diseases caused by Mycobacterium tuberculosis (M.TB) with millions of people dying every year. Emergence of new cases, increased incidence of multi drug resistant strains of M.TB and the adverse effects of first and second line antitubercular drugs have led to renewed interest in natural products with the hope of discovering new antitubercular leads. Coumarins and chalcones are plant deriv Read More

Background: The reign of allergic infections caused by pathogenic fungi during the past few decades has created a major concern among healthcare professionals. Fungal allergens cause allergic manifestations in atopic and healthy individuals as well. The presence of T-cell and B-cell epitopes is essential for a protein to be an allergen and sharing of these epitopes make the allergens cross reactive that is a major issue Read More

Background: Microemulsion is one of the promising sub-micron carriers for topical drug delivery as it offers advantages like high drug-loading capacity and good skin penetration. Microemulsion based gel of voriconazole (broad-spectrum antifungal agent) could be an effective strategy for treatment of topical fungal infections. Objective: To develop microemulsion based hydrogel of voriconazole was for effective treatment Read More

Background: The large scale growing and harvesting of Calamus aromaticus, a medicinally important weed, is rampant in Asia due to its well-known medicinal importance. The gigantic antimicrobial potential of C. aromaticus, however, is not reflected in the absolute sense by the efforts devoted to this purpose so far. Methods: The role of Gallic acid in the determination of antibacterial potency was established by first assessing th Read More

Background: Glycoprotein120 (GP120) is an emerging target nowadays to design novel human immunodeficiency virus-1 (HIV-1) entry inhibitors. It plays a crucial role in the first stage of viral attachment through binding to CD4 receptors of host cell but currently there is no approved drug in the market targeting this HIV-1 GP120. Thus, there is an urge of novel lead molecules as GP120-CD4 binding inhibitors. Methods: To design s Read More

Background: Heterocyclic compounds have attracted much attention to synthetic and medicinal chemists because of their biological activities especially for tuberculosis (TB).Moreover, fatal forms of TB (including tuberculous meningitis) have led to search for new structural anti-TB agents. So, we have built a scaffold using imidazo[1,2-b]pyridazine, piperazine and morpholine moieties, which are widely used in the inhibition o Read More