Anti-Infective Agents - Volume 15, Issue 1, 2017

Introduction: With the development of the direct acting antivirals aganist hepatitis C virus (HCV), the treatment of HCV has showed significiant progress. However, hepatitis B virus (HBV) therapy is still a topic of discussion. Objectives: Because of that approved agents for HBV have some disadvantages including indefinite therapy, drug resistance, adverse effects and persistence of covalently closed circular deoxyribonucle Read More

The report is an overview of the scientific presentations at the 36th International Symposium on Intensive Care and Emergency Medicine (ISICEM) which were related to fungal infections with a specific focus on Candidiasis. Key topics covered include Candida infections associated with the increase in incidence of sepsis in intensive care units, emerging strategies for early identification of appropriate patients for empiric anti Read More

Background: Severe acute liver failure by Epstein-Barr virus is a rare event. A specific antiviral treatment is not available and steroid use is controversial. Objective: We report the beneficial effect of steroid therapy in this clinical condition. Case Report: We observed the case of a 19-year male patient admitted to our Gastroenterology Unit for an acute Epstein-Barr virus-related hepatitis (significant transaminase flare: aspa Read More

The European Society for Blood and Marrow Transplantation (EBMT), established in 1974, is the leading scientific society for professionals involved in haematopoietic stem-cell transplantation (HSCT). The 2016 EBMT Annual Meeting, held in Valencia, Spain, brought together over 4,500 scientists, physicians, nurses, biologists, pharmacists, technicians and patients to discuss scientific data across a wide range of topics. New for this Read More

Background: A series of new symmetric disulfonamide and dicarbamate derivatives of 4,4#136;-oxydianiline were designed and synthesized in a simple method. These compounds were characterized by IR, 1H, 13C-NMR, mass spectral data and elemental analysis. Method: The compounds were screened for their in vitro antibacterial and antifungal activities against various pathogenic organisms. Among the title compounds Read More

Introduction: Aegle marmelos (L.) Correa, a member of the Rutaceae family, is a very common fruit and medicinal plant in Bangladesh. The seeds of Aegle marmelos has showed important therapeutic applications like Antiulcer, Phytoremediation , Antimicrobial , Antidiabeic and Neuroprotective role. Materials and Method: In the present investigation, methanol, ethyl acetate and chloroform extracts of A. marmelos seeds were as Read More

Background: The emergence of multi-drug resistant and extensively drug-resistant cases of tuberculosis has lead to the search for new structural classes of anti-tuberculosis drugs. There are many reports on antimycobacterial screening of compounds containing the 4-thiazolidinone moiety. The 5- arylidene moiety in the 2-heteroarylimino-5-benzylidene-4-thiazolidinone scaffold plays an important role in antimicrobial activity Read More

Background: The pyrazole moiety hold a unique position in heterocyclic chemistry. Novel pyrazole scaffolds with more potency can be very effective against resistant strains of various microorganisms. Objective: To carry out the synthesis, characterization and antimicrobial screening of novel 3, 5 dimethyl pyrazole analogs. Method: A series of novel pyrazole scaffolds were synthesized by treating 3, 5 dimethyl pyrazole with various Read More

In HCV genome, the NS5B RNA-dependent RNA polymerase (RdRp) plays central role in the replication. It is the most preferred target for design and screening of small molecule HCV inhibitors. From in house compound library screening using NS5B polymerase enzymatic assay, we identified some benzimidazole derivatives. The activities were predicted using the QSAR generated models. Along with QSAR predictions, molecul Read More

Introduction: Leishmaniasis is an endemic disease caused by the protozoan parasite Leishmania. Current treatments for the parasite are limited by cost, availability and drug resistance as the occurrence of leishmaniasis continues to be more prevalent. Sulfonamides are a class of compounds with medicinal properties which have been used to treat bacterial and parasitic disease via various pathways especially as antimetabolit Read More

Helicobacter pylori (H. pylori) is the only unique microorganism that has been linked to cancer. Although many therapeutic lines have been modified we are still lacking with the successful formulation to treat and manage the infection. Later, probiotics have been introduced as an alternative increasing the efficacy of antimicrobial agents. Probiotics include several microorganisms, mostly Lactobacillus which can be listed as te Read More