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Volume 23, Issue 2
  • ISSN: 2211-3525
  • E-ISSN: 2211-3533

Abstract

Background and Aim

Mosquitoes significantly threaten public health, transmitting dangerous diseases to humans and animals. Conventional insecticide spraying, while common, has limitations in effectively controlling vector-borne diseases. Many chemical pesticides harm humans and animals, and some persist in the environment and cause toxic effects. Recently, there has been renewed interest in plant-based products due to concerns about insecticide resistance, cross-resistance, potential toxicity associated with synthetic options, and rising costs. Therefore, this study aimed to screen the and phytochemicals targeting the odorant binding proteins (OBPs) of and .

Methods

In this study, we conducted molecular docking analyses using specific plant-derived compounds from and .

Results

We focused on the interaction of these compounds with OBPs from dengue and chikungunya vectors ( and ). The selected phytochemical compounds exhibited strong binding with the OBP of both and . Tetrahydrofuran-2-carboxylic acid, Carvacryl acetate, and Brallobarbital showed high binding affinity and significant interaction with . Tetrahydrofuran-2-carboxylic acid and 3-Methyl-4-isopropylphenol also demonstrated substantial binding affinity and effective interaction with OBP.

Conclusion

These findings suggest that the identified compounds can potentially disrupt the attraction of mosquitoes to humans, thus reducing human-vector contact. They may offer a promising alternative for developing natural and efficient mosquito repellents, surpassing currently used synthetic options like N, N-diethyl-meta-toluamide, and other conventional repellents.

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2025-01-16

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In silico Screening of Plectranthus amboinicus and Hyptis suaveolens Phytochemicals: Novel Repellents Targeting Odorant Binding Proteins of Aedes aegypti and Aedes albopictus
Anti Infect. Agents 23, E080724231716 (2025); https://doi.org/10.2174/0122113525306071240613043139
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  • Article Type:     Research Article
Keyword(s): Aedes aegypti; Aedes albopictus; Hyptis suaveolens; molecular docking; N-diethyl-meta-toluamide; Plectranthus amboinicus

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