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Volume 23, Issue 2
  • ISSN: 2211-3525
  • E-ISSN: 2211-3533

Abstract

Background

Antiviral compounds from plant origin have been the focus of researchers throughout the world for a long time as the potential alternative to classical antiviral therapies. The search for antiviral phytochemicals comes into the limelight amidst the recent COVID-19 pandemic. This tremendous surge in the hunt for effective and alternative treatment from the plant source is mainly due to the toxicity and inadequate responses of synthetic antiviral drugs to resistant viral strains.

Methods

A comprehensive literature survey on the antiviral activity of bioactive compounds from the genus was conducted using known and widely acknowledged scientific databases.

Results

This in-depth review is prepared to shed light on the promising effect of the bioactive phytochemicals isolated from different spp. against some of the most pathogenically relevant viruses such as Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2), Human Immunodeficiency Virus (HIV), Influenza Virus, Hepatitis C Virus (HCV), Herpes Simplex Virus (HSV), Japanese Encephalitis Virus (JEV), Dengue Virus (DENV), and Chikungunya Virus (CHIKV). Bioactive compounds such as ursolic acid, sugiol, and quercetin are reported to prevent virus-host cell adhesion. Harpagide is found to reduce intracellular Ca2+ and mitochondrial stress in infected cells, preventing viral infection. Researchers reported the efficacy of β-sitosterol in inhibiting immune responses RIG-I signalling and IFN production. Rengyolone is found to mitigate viral infection by preventing acute inflammation. Betulinic acid, tricin, and oleanolic acid are found to prevent IAV and HIV replication. Evidence has also suggested the possible action of kaempferol, acacetin and apigenin to inhibit mRNA and protein production in virus-infected cells.

Conclusion

Future research should be oriented towards the isolation and quantitation of these bioactive compounds from , along with their efficacy both and prior to their clinical applications in combating a variety of viral infections.

© 2025 Bentham Science Publishers
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2025-01-16

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/content/journals/aia/10.2174/0122113525305139240629084443
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Insight into the Potential Antiviral Properties of the Genus Clerodendrum: Bioactive compounds with Mechanism of Action
Anti Infect. Agents 23, E230724232193 (2025); https://doi.org/10.2174/0122113525305139240629084443
/content/journals/aia/10.2174/0122113525305139240629084443
/content/journals/aia/10.2174/0122113525305139240629084443
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  • Article Type:     Review Article
Keyword(s): antiviral compounds; Clerodendrum spp.; dengue virus; HIV; SARS-CoV-2; viral pathogenesis

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