The development of an efficient and innovative drug delivery system is essential to improve the pharmacological parameters of the medicinal compound or drug. The technique or manner used to improve the pharmacological parameters plays a crucial role in the delivery system. In the current scenario various drug delivery systems are available where nanotechnology has firmly established itself in the field of drug delivery. One of the most prevalent ele Read More

Background: Nanotechnology has gained enormous attention in pharmaceutical research. Nanotechnology is used in the development of nanoparticles with sizes ranging from 1-100 nm with several extraordinary features. Metallic nanoparticles (MNPs) are used in various areas such as molecular biology biosensors bio imaging biomedical devices diagnosis pharmaceuticals etc. for their specific applications. Methodology: For this study we have perf Read More

Croton cajucara Benth showed several pharmacological properties such as: antiinflammatory antinociceptive hypoglycemic lipid-lowering antiulcer antiestrogenic antitumor antigenotoxic antimutagenic and cardiovascular. The 19-nor-clerodane diterpene transdehydrocrotonin (t-DCTN or DCTN) is the major bioactive constituent extracted from the bark of this Croton. Patents for Croton cajucara Benth in the period 2015 to 2022 comprises 14 pu Read More

As per International Diabetes Federation Report 2022 worldwide diabetes mellitus (DM) caused 6.7M moralities and ~537M adults suffering from diabetes mellitus. It is a chronic condition due to β-cell destruction or insulin resistance that leads to insulin deficiency. This review discusses Type-1 DM and Type-2 DM pathophysiology in detail with challenges in management and treatment. The toxicity issues of conventional drugs and insulin injections are compl Read More

Introduction: In the present study solid lipid nanoparticles loaded with Rosiglitazone and probiotics were prepared via solvent emulsification diffusion method which is patented. As a lipid and surfactant Gleceryl monostearate and Pluronic -68 were used in the formulation process. Methods: During characterization it was determined that ingredient quantity variations significantly impacted Rosiglitazone loading capacity particle size polydispersity index etc. In an Read More

Objective To investigate the underlying mechanism by which quercetin (Que) regulates macrophage polarization and its subsequent therapeutic effect on liver fibrosis an important pathological precondition for hepatocellular carcinoma (HCC). Methods In vitro experiments were performed on the RAW264.7 mouse macrophage line. After the induction of M1-type macrophages with LPS the effects of Que on cell morphology M1/M2 surface marker expr Read More

Background: An autoimmune-mediated dermatological ailment featuring recurrent episodes is acknowledged as psoriasis. Around the world 2–3% of people suffer from this autoimmune skin condition. Objectives: The primary goal of the current review is to analyse and determine the effectiveness of conventional and emerging nano technological strategies to alleviate psoriasis and discuss future perspectives. Methods: A thorough search of numerous electr Read More

Background: Lepidium sativum (LS) seed extract has various pharmacological properties such as antioxidant hepatoprotective and anticancer activities. However the translation of L. sativum seed extract to the clinical phase is still tedious due to its bioavailability and stability issues. This problem can be solved by encapsulating it in a nanodelivery system to improve its therapeutic potency. Methods: In this study we have determined and compared the in v Read More