Skip to content
2000
Volume 19, Issue 3
  • ISSN: 2772-2708
  • E-ISSN: 2772-2716

Abstract

Objectives

This study aimed to characterize oral and gut microbiota of children with high dmft index and caries-free children at phylum, family and species levels as well as to evaluate the effect of M18 DSM 14685 (Carioblis) administration on microbiota composition of caries active children.

Materials and Methods

Ten children with active caries and nine caries-free children have been recruited. Four samples from different oral niches and stools were collected from each patient for the NGS sequencing of 16s Microbiota rDNA by S5 Ion Torrent.

Results

Our results revealed modifications in the microbiota composition of teeth, saliva and vestibular regions of the oral cavity and faecal samples in the presence of dental caries. These changes were evident at the family and species levels, with no significant differences found at the phylum composition level. In particular, Streptococcaceae were positively correlated to the high degree of caries in all niches, and the analysis at the species level led to the identification of 39 bacterial species significantly modulated in the analyzed groups. The use of probiotic seemed to exert beneficial effects on oral but not on faeces dysbiosis. The intestinal tract was confirmed to have a different microbiota composition compared to the oral cavity.

Conclusion

Dental caries mainly lead to modifications in the oral microbiota composition. DSM 14685 administration determines a shift in the oral microbiota composition towards a healthier state. Concerning the gastrointestinal tract, our study found for the first time that caries cause the increase of two bacterial species, related to other disorders: and .

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/raiad/10.2174/0127722708335159241117062704
2024-12-04
2026-02-21

  • From This Site

    /content/journals/raiad/10.2174/0127722708335159241117062704
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. Guideline on management of the developing dentition and occlusion in pediatric dentistry.Pediatr. Dent.199027143155
     [Google Scholar]
  2. WangY. WangS. WuC. ChenX. DuanZ. XuQ. JiangW. XuL. WangT. SuL. WangY. ChenY. ZhangJ. HuangY. TongS. ZhouC. DengS. QinN. Oral microbiome alterations associated with early childhood caries highlight the importance of carbohydrate metabolic activities.mSystems20194600450-1910.1128/msystems.00450‑1931690590
     [Google Scholar]
  3. JamesS.L. AbateD. AbateK.H. AbayS.M. AbbafatiC. AbbasiN. AbbastabarH. Abd-AllahF. AbdelaJ. AbdelalimA. AbdollahpourI. AbdulkaderR.S. AbebeZ. AberaS.F. AbilO.Z. AbrahaH.N. Abu-RaddadL.J. Abu-RmeilehN.M.E. AccrombessiM.M.K. AcharyaD. AcharyaP. AckermanI.N. AdamuA.A. AdebayoO.M. AdekanmbiV. AdetokunbohO.O. AdibM.G. AdsuarJ.C. AfanviK.A. AfaridehM. AfshinA. AgarwalG. AgesaK.M. AggarwalR. AghayanS.A. AgrawalS. AhmadiA. AhmadiM. AhmadiehH. AhmedM.B. AichourA.N. AichourI. AichourM.T.E. AkinyemijuT. AkseerN. Al-AlyZ. Al-EyadhyA. Al-MekhlafiH.M. Al-RaddadiR.M. AlahdabF. AlamK. AlamT. AlashiA. AlavianS.M. AleneK.A. AlijanzadehM. Alizadeh-NavaeiR. AljunidS.M. AlkerwiA. AllaF. AllebeckP. AlouaniM.M.L. AltirkawiK. Alvis-GuzmanN. AmareA.T. AmindeL.N. AmmarW. AmoakoY.A. AnberN.H. AndreiC.L. AndroudiS. AnimutM.D. AnjomshoaM. AnshaM.G. AntonioC.A.T. AnwariP. ArablooJ. ArauzA. AremuO. ArianiF. ArmoonB. ÄrnlövJ. AroraA. ArtamanA. AryalK.K. AsayeshH. AsgharR.J. AtaroZ. AtreS.R. AusloosM. Avila-BurgosL. AvokpahoE.F.G.A. AwasthiA. Ayala QuintanillaB.P. AyerR. AzzopardiP.S. BabazadehA. BadaliH. BadawiA. BaliA.G. BallesterosK.E. BallewS.H. BanachM. BanoubJ.A.M. BanstolaA. BaracA. BarbozaM.A. Barker-ColloS.L. BärnighausenT.W. BarreroL.H. BauneB.T. Bazargan-HejaziS. BediN. BeghiE. BehzadifarM. BehzadifarM. BéjotY. BelachewA.B. BelayY.A. BellM.L. BelloA.K. BensenorI.M. BernabeE. BernsteinR.S. BeuranM. BeyranvandT. BhalaN. BhattaraiS. BhaumikS. BhuttaZ.A. BiadgoB. BijaniA. BikbovB. BilanoV. BililignN. Bin SayeedM.S. BisanzioD. BlackerB.F. BlythF.M. Bou-OrmI.R. BoufousS. BourneR. BradyO.J. BraininM. BrantL.C. BrazinovaA. BreitbordeN.J.K. BrennerH. BriantP.S. BriggsA.M. BrikoA.N. BrittonG. BrughaT. BuchbinderR. BusseR. ButtZ.A. Cahuana-HurtadoL. CanoJ. CárdenasR. CarreroJ.J. CarterA. CarvalhoF. Castañeda-OrjuelaC.A. Castillo RivasJ. CastroF. Catalá-LópezF. CercyK.M. CerinE. ChaiahY. ChangA.R. ChangH-Y. ChangJ-C. CharlsonF.J. ChattopadhyayA. ChattuV.K. ChaturvediP. ChiangP.P-C. ChinK.L. ChitheerA. ChoiJ-Y.J. ChowdhuryR. ChristensenH. ChristopherD.J. CicuttiniF.M. CiobanuL.G. CirilloM. ClaroR.M. Collado-MateoD. CooperC. CoreshJ. CortesiP.A. CortinovisM. CostaM. CousinE. CriquiM.H. CromwellE.A. CrossM. CrumpJ.A. DadiA.F. DandonaL. DandonaR. DarganP.I. DaryaniA. Das GuptaR. Das NevesJ. DasaT.T. DaveyG. DavisA.C. DavitoiuD.V. De CourtenB. De La HozF.P. De LeoD. De NeveJ-W. DegefaM.G. DegenhardtL. DeiparineS. DellavalleR.P. DemozG.T. DeribeK. DervenisN. Des JarlaisD.C. DessieG.A. DeyS. DharmaratneS.D. DinberuM.T. DiracM.A. DjalaliniaS. DoanL. DokovaK. DokuD.T. DorseyE.R. DoyleK.E. DriscollT.R. DubeyM. DubljaninE. DukenE.E. DuncanB.B. DuraesA.R. EbrahimiH. EbrahimpourS. EchkoM.M. EdvardssonD. EffiongA. EhrlichJ.R. El BcheraouiC. El Sayed ZakiM. El-KhatibZ. ElkoutH. ElyazarI.R.F. EnayatiA. EndriesA.Y. ErB. ErskineH.E. EshratiB. EskandariehS. EsteghamatiA. EsteghamatiS. FakhimH. Fallah OmraniV. FaramarziM. FareedM. FarhadiF. FaridT.A. FarinhaC.S.E. FarioliA. FaroA. FarvidM.S. FarzadfarF. FeiginV.L. FentahunN. FereshtehnejadS-M. FernandesE. FernandesJ.C. FerrariA.J. FeyissaG.T. FilipI. FischerF. FitzmauriceC. FoigtN.A. ForemanK.J. FoxJ. FrankT.D. FukumotoT. FullmanN. FürstT. FurtadoJ.M. FutranN.D. GallS. GanjiM. GankpeF.G. Garcia-BasteiroA.L. GardnerW.M. GebreA.K. GebremedhinA.T. GebremichaelT.G. GelanoT.F. GeleijnseJ.M. Genova-MalerasR. GeramoY.C.D. GethingP.W. GezaeK.E. GhadiriK. Ghasemi FalavarjaniK. Ghasemi-KasmanM. GhimireM. GhoshR. GhoshalA.G. GiampaoliS. GillP.S. GillT.K. GinawiI.A. GiussaniG. GnedovskayaE.V. GoldbergE.M. GoliS. Gómez-DantésH. GonaP.N. GopalaniS.V. GormanT.M. GoulartA.C. GoulartB.N.G. GradaA. GramsM.E. GrossoG. GugnaniH.C. GuoY. GuptaP.C. GuptaR. GuptaR. GuptaT. GyawaliB. HaagsmaJ.A. HachinskiV. Hafezi-NejadN. Haghparast BidgoliH. HagosT.B. HailuG.B. Haj-MirzaianA. Haj-MirzaianA. HamadehR.R. HamidiS. HandalA.J. HankeyG.J. HaoY. HarbH.L. HarikrishnanS. HaroJ.M. HasanM. HassankhaniH. HassenH.Y. HavmoellerR. HawleyC.N. HayR.J. HayS.I. Hedayatizadeh-OmranA. HeibatiB. HendrieD. HenokA. HerteliuC. HeydarpourS. HibstuD.T. HoangH.T. HoekH.W. HoffmanH.J. HoleM.K. Homaie RadE. HoogarP. HosgoodH.D. HosseiniS.M. HosseinzadehM. HostiucM. HostiucS. HotezP.J. HoyD.G. HsairiM. HtetA.S. HuG. HuangJ.J. HuynhC.K. IburgK.M. IkedaC.T. IleanuB. IlesanmiO.S. IqbalU. IrvaniS.S.N. IrvineC.M.S. IslamS.M.S. IslamiF. JacobsenK.H. JahangiryL. JahanmehrN. JainS.K. JakovljevicM. JavanbakhtM. JayatillekeA.U. JeemonP. JhaR.P. JhaV. JiJ.S. JohnsonC.O. JonasJ.B. JozwiakJ.J. JungariS.B. JürissonM. KabirZ. KadelR. KahsayA. KalaniR. KanchanT. KaramiM. Karami MatinB. KarchA. KaremaC. KarimiN. KarimiS.M. KasaeianA. KassaD.H. KassaG.M. KassaT.D. KassebaumN.J. KatikireddiS.V. KawakamiN. KaryaniA.K. KeighobadiM.M. KeiyoroP.N. KemmerL. KempG.R. KengneA.P. KerenA. KhaderY.S. KhafaeiB. KhafaieM.A. KhajaviA. KhalilI.A. KhanE.A. KhanM.S. KhanM.A. KhangY-H. KhazaeiM. KhojaA.T. KhosraviA. KhosraviM.H. KiadaliriA.A. KiirithioD.N. KimC-I. KimD. KimP. KimY-E. KimY.J. KimokotiR.W. KinfuY. KisaA. Kissimova-SkarbekK. KivimäkiM. KnudsenA.K.S. KocarnikJ.M. KochharS. KokuboY. KololaT. KopecJ.A. KosenS. KotsakisG.A. KoulP.A. KoyanagiA. KravchenkoM.A. KrishanK. KrohnK.J. Kuate DefoB. Kucuk BicerB. KumarG.A. KumarM. KyuH.H. LadD.P. LadS.D. LafranconiA. LallooR. LallukkaT. LamiF.H. LansinghV.C. LatifiA. LauK.M-M. LazarusJ.V. LeasherJ.L. LedesmaJ.R. LeeP.H. LeighJ. LeungJ. LeviM. LewyckaS. LiS. LiY. LiaoY. LibenM.L. LimL-L. LimS.S. LiuS. LodhaR. LookerK.J. LopezA.D. LorkowskiS. LotufoP.A. LowN. LozanoR. LucasT.C.D. LucchesiL.R. LuneviciusR. LyonsR.A. MaS. MacarayanE.R.K. MackayM.T. MadottoF. Magdy Abd El RazekH. Magdy Abd El RazekM. MaghavaniD.P. MahotraN.B. MaiH.T. MajdanM. MajdzadehR. MajeedA. MalekzadehR. MaltaD.C. MamunA.A. MandaA-L. ManguerraH. ManhertzT. MansourniaM.A. MantovaniL.G. MapomaC.C. MaravillaJ.C. MarcenesW. MarksA. Martins-MeloF.R. MartopulloI. MärzW. MarzanM.B. Mashamba-ThompsonT.P. MassenburgB.B. MathurM.R. MatsushitaK. MaulikP.K. MazidiM. McAlindenC. McGrathJ.J. McKeeM. MehndirattaM.M. MehrotraR. MehtaK.M. MehtaV. Mejia-RodriguezF. MekonenT. MeleseA. MelkuM. MeltzerM. MemiahP.T.N. MemishZ.A. MendozaW. MengistuD.T. MengistuG. MensahG.A. MeretaS.T. MeretojaA. MeretojaT.J. MestrovicT. MezerjiN.M.G. MiazgowskiB. MiazgowskiT. MillearA.I. MillerT.R. MiltzB. MiniG.K. MirarefinM. MirrakhimovE.M. MisganawA.T. MitchellP.B. MitikuH. MoazenB. MohajerB. MohammadK.A. MohammadifardN. Mohammadnia-AfrouziM. MohammedM.A. MohammedS. MohebiF. MoitraM. MokdadA.H. MolokhiaM. MonastaL. MoodleyY. MoosazadehM. MoradiG. Moradi-LakehM. MoradinazarM. MoragaP. MorawskaL. Moreno VelásquezI. Morgado-Da-CostaJ. MorrisonS.D. MoschosM.M. Mountjoy-VenningW.C. MousaviS.M. MrutsK.B. MucheA.A. MuchieK.F. MuellerU.O. MuhammedO.S. MukhopadhyayS. MullerK. MumfordJ.E. MurhekarM. MusaJ. MusaK.I. MustafaG. NabhanA.F. NagataC. NaghaviM. NaheedA. NahvijouA. NaikG. NaikN. NajafiF. NaldiL. NamH.S. NangiaV. NansseuJ.R. NascimentoB.R. NatarajanG. NeamatiN. NegoiI. NegoiR.I. NeupaneS. NewtonC.R.J. NgunjiriJ.W. NguyenA.Q. NguyenH.T. NguyenH.L.T. NguyenH.T. NguyenL.H. NguyenM. NguyenN.B. NguyenS.H. NicholsE. NingrumD.N.A. NixonM.R. NolutshunguN. NomuraS. NorheimO.F. NorooziM. NorrvingB. NoubiapJ.J. NouriH.R. Nourollahpour ShiadehM. NowrooziM.R. NsoesieE.O. NyasuluP.S. OdellC.M. Ofori-AsensoR. OgboF.A. OhI-H. OladimejiO. OlagunjuA.T. OlagunjuT.O. OlivaresP.R. OlsenH.E. OlusanyaB.O. OngK.L. OngS.K. OrenE. OrtizA. OtaE. OtstavnovS.S. ØverlandS. OwolabiM.O. P AM. PacellaR. PakpourA.H. PanaA. Panda-JonasS. ParisiA. ParkE-K. ParryC.D.H. PatelS. PatiS. PatilS.T. PatleA. PattonG.C. PaturiV.R. PaulsonK.R. PearceN. PereiraD.M. PericoN. PesudovsK. PhamH.Q. PhillipsM.R. PigottD.M. PillayJ.D. PiradovM.A. PirsahebM. PishgarF. Plana-RipollO. PlassD. PolinderS. PopovaS. PostmaM.J. PourshamsA. PoustchiH. PrabhakaranD. PrakashS. PrakashV. PurcellC.A. PurwarM.B. QorbaniM. QuistbergD.A. RadfarA. RafayA. RafieiA. RahimF. RahimiK. Rahimi-MovagharA. Rahimi-MovagharV. RahmanM. RahmanM.H. RahmanM.A. RahmanS.U. RaiR.K. RajatiF. RamU. RanjanP. RantaA. RaoP.C. RawafD.L. RawafS. ReddyK.S. ReinerR.C. ReinigN. ReitsmaM.B. RemuzziG. RenzahoA.M.N. ResnikoffS. RezaeiS. RezaiM.S. RibeiroA.L.P. RobertsN.L.S. RobinsonS.R. RoeverL. RonfaniL. RoshandelG. RostamiA. RothG.A. RoyA. RubagottiE. SachdevP.S. SadatN. SaddikB. SadeghiE. Saeedi MoghaddamS. SafariH. SafariY. Safari-FaramaniR. SafdarianM. SafiS. SafiriS. SagarR. SahebkarA. SahraianM.A. SajadiH.S. SalamN. SalamaJ.S. SalamatiP. SaleemK. SaleemZ. SalimiY. SalomonJ.A. SalviS.S. SalzI. SamyA.M. SanabriaJ. SangY. SantomauroD.F. SantosI.S. SantosJ.V. Santric MilicevicM.M. Sao JoseB.P. SardanaM. SarkerA.R. SarrafzadeganN. SartoriusB. SarviS. SathianB. SatpathyM. SawantA.R. SawhneyM. SaxenaS. SaylanM. SchaeffnerE. SchmidtM.I. SchneiderI.J.C. SchöttkerB. SchwebelD.C. SchwendickeF. ScottJ.G. SekerijaM. SepanlouS.G. Serván-MoriE. SeyedmousaviS. ShabaninejadH. ShafieesabetA. ShahbaziM. ShaheenA.A. ShaikhM.A. Shams-BeyranvandM. ShamsiM. ShamsizadehM. SharafiH. SharafiK. SharifM. Sharif-AlhoseiniM. SharmaM. SharmaR. SheJ. SheikhA. ShiP. ShibuyaK. ShigematsuM. ShiriR. ShirkoohiR. ShishaniK. ShiueI. ShokranehF. ShomanH. ShrimeM.G. SiS. SiabaniS. SiddiqiT.J. SigfusdottirI.D. SigurvinsdottirR. SilvaJ.P. SilveiraD.G.A. SingamN.S.V. SinghJ.A. SinghN.P. SinghV. SinhaD.N. SkiadaresiE. SlepakE.L.N. SliwaK. SmithD.L. SmithM. Soares FilhoA.M. SobaihB.H. SobhaniS. SobngwiE. SonejiS.S. SoofiM. SoosaraeiM. SorensenR.J.D. SorianoJ.B. SoyiriI.N. SposatoL.A. SreeramareddyC.T. SrinivasanV. StanawayJ.D. SteinD.J. SteinerC. SteinerT.J. StokesM.A. StovnerL.J. SubartM.L. SudaryantoA. SufiyanM.B. SunguyaB.F. SurP.J. SutradharI. SykesB.L. SylteD.O. Tabarés-SeisdedosR. TadakamadlaS.K. TadesseB.T. TandonN. TassewS.G. TavakkoliM. TaveiraN. TaylorH.R. Tehrani-BanihashemiA. TekalignT.G. TekelemedhinS.W. TekleM.G. TemesgenH. TemsahM-H. TemsahO. TerkawiA.S. TeweldemedhinM. ThankappanK.R. ThomasN. TilahunB. ToQ.G. TonelliM. Topor-MadryR. TopouzisF. TorreA.E. Tortajada-GirbésM. TouvierM. Tovani-PaloneM.R. TowbinJ.A. TranB.X. TranK.B. TroegerC.E. TruelsenT.C. TsilimbarisM.K. TsoiD. Tudor CarL. TuzcuE.M. UkwajaK.N. UllahI. UndurragaE.A. UnutzerJ. UpdikeR.L. UsmanM.S. UthmanO.A. VaduganathanM. VaeziA. ValdezP.R. VarugheseS. VasankariT.J. VenketasubramanianN. VillafainaS. ViolanteF.S. VladimirovS.K. VlassovV. VollsetS.E. VosoughiK. VujcicI.S. WagnewF.S. WaheedY. WallerS.G. WangY. WangY-P. WeiderpassE. WeintraubR.G. WeissD.J. WeldegebrealF. WeldegwergsK.G. WerdeckerA. WestT.E. WhitefordH.A. WideckaJ. WijeratneT. WilnerL.B. WilsonS. WinklerA.S. WiyehA.B. WiysongeC.S. WolfeC.D.A. WoolfA.D. WuS. WuY-C. WyperG.M.A. XavierD. XuG. YadgirS. YadollahpourA. Yahyazadeh JabbariS.H. YamadaT. YanL.L. YanoY. YaseriM. YasinY.J. YeshanehA. YimerE.M. YipP. YismaE. YonemotoN. YoonS-J. YotebiengM. YounisM.Z. YousefifardM. YuC. ZadnikV. ZaidiZ. ZamanS.B. ZamaniM. ZareZ. ZelekeA.J. ZenebeZ.M. ZhangK. ZhaoZ. ZhouM. ZodpeyS. ZuckerI. VosT. MurrayC.J.L. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017.Lancet2018392101591789185810.1016/S0140‑6736(18)32279‑730496104
     [Google Scholar]
  4. PhantumvanitP. MakinoY. OgawaH. Rugg-GunnA. MoynihanP. PetersenP.E. EvansW. FeldensC.A. LoE. KhoshnevisanM.H. BaezR. VarenneB. VichayanratT. SongpaisanY. WoodwardM. NakornchaiS. UngchusakC. WHO Global Consultation on Public Health Intervention against Early Childhood Caries.Community Dent. Oral Epidemiol.201846328028710.1111/cdoe.1236229380407
     [Google Scholar]
  5. CasamassimoP.S. ThikkurissyS. EdelsteinB.L. MaioriniE. Beyond the dmft.J. Am. Dent. Assoc.2009140665065710.14219/jada.archive.2009.025019491160
     [Google Scholar]
  6. LoescheW.J. Role of Streptococcus mutans in human dental decay.Microbiol. Rev.198650435338010.1128/mr.50.4.353‑380.19863540569
     [Google Scholar]
  7. RupfS. MerteK. EschrichK. KneistS. Streptococcus sobrinus in children and its influence on caries activity.Eur. Arch. Paediatr. Dent.200611172210.1007/BF0332081017140523
     [Google Scholar]
  8. AasJ.A. GriffenA.L. DardisS.R. LeeA.M. OlsenI. DewhirstF.E. LeysE.J. PasterB.J. Bacteria of dental caries in primary and permanent teeth in children and young adults.J. Clin. Microbiol.20084641407141710.1128/JCM.01410‑0718216213
     [Google Scholar]
  9. XuH. HaoW. ZhouQ. WangW. XiaZ. LiuC. ChenX. QinM. ChenF. Plaque bacterial microbiome diversity in children younger than 30 months with or without caries prior to eruption of second primary molars.PLoS One201492e8926910.1371/journal.pone.008926924586647
     [Google Scholar]
  10. TakahashiN. NyvadB. The role of bacteria in the caries process: ecological perspectives.J. Dent. Res.201190329430310.1177/002203451037960220924061
     [Google Scholar]
  11. PetersonJ. GargesS. GiovanniM. McInnesP. WangL. SchlossJ.A. BonazziV. McEwenJ.E. WetterstrandK.A. DealC. BakerC.C. Di FrancescoV. HowcroftT.K. KarpR.W. LunsfordR.D. WellingtonC.R. BelachewT. WrightM. GiblinC. DavidH. MillsM. SalomonR. MullinsC. AkolkarB. BeggL. DavisC. GrandisonL. HumbleM. KhalsaJ. LittleA.R. PeavyH. PontzerC. PortnoyM. SayreM.H. Starke-ReedP. ZakhariS. ReadJ. WatsonB. GuyerM. NIH HMP Working Group The NIH Human Microbiome Project.Genome Res.200919122317232310.1101/gr.096651.10919819907
     [Google Scholar]
  12. FechneyJ.M. BrowneG.V. PrabhuN. IrinyiL. MeyerW. HughesT. BockmannM. TownsendG. SalehiH. AdlerC.J. Preliminary study of the oral mycobiome of children with and without dental caries.J. Oral Microbiol.2019111153618210.1080/20002297.2018.153618230598729
     [Google Scholar]
  13. Cornejo UlloaP. van der VeenM.H. KromB.P. Review: modulation of the oral microbiome by the host to promote ecological balance.Odontology2019107443744810.1007/s10266‑019‑00413‑x30719639
     [Google Scholar]
  14. SantacroceL. PassarelliP.C. AzzolinoD. BottalicoL. CharitosI.A. CazzollaA.P. ColellaM. TopiS. GodoyF.G. D’AddonaA. Oral microbiota in human health and disease: A perspective.Exp. Biol. Med. (Maywood)2023248151288130110.1177/1535370223118764537688509
     [Google Scholar]
  15. LamontR.J. KooH. HajishengallisG. The oral microbiota: dynamic communities and host interactions.Nat. Rev. Microbiol.2018161274575910.1038/s41579‑018‑0089‑x30301974
     [Google Scholar]
  16. YamashitaY. TakeshitaT. The oral microbiome and human health.J. Oral Sci.201759220120610.2334/josnusd.16‑085628637979
     [Google Scholar]
  17. Sampaio-MaiaB. CaldasI.M. PereiraM.L. Pérez-MongioviD. AraujoR. The Oral Microbiome in Health and Its Implication in Oral and Systemic Diseases.Adv. Appl. Microbiol.20169717121010.1016/bs.aambs.2016.08.00227926431
     [Google Scholar]
  18. FakhruddinK.S. NgoH.C. SamaranayakeL.P. Cariogenic microbiome and microbiota of the early primary dentition: A contemporary overview.Oral Dis.201925498299510.1111/odi.1293229969843
     [Google Scholar]
  19. JandhyalaS.M. TalukdarR. SubramanyamC. VuyyuruH. SasikalaM. Nageshwar ReddyD. Role of the normal gut microbiota.World J. Gastroenterol.201521298787880310.3748/wjg.v21.i29.878726269668
     [Google Scholar]
  20. ClarkeG. SandhuK.V. GriffinB.T. DinanT.G. CryanJ.F. HylandN.P. Gut Reactions: Breaking Down Xenobiotic–Microbiome Interactions.Pharmacol. Rev.201971219822410.1124/pr.118.01576830890566
     [Google Scholar]
  21. JohnsonK.V.A. FosterK.R. Why does the microbiome affect behaviour?Nat. Rev. Microbiol.2018161064765510.1038/s41579‑018‑0014‑329691482
     [Google Scholar]
  22. RodriguesJ.Z.S. PassosM.R. Silva de Macêdo NeresN. AlmeidaR.S. PitaL.S. SantosI.A. Santana SilveiraP.H. ReisM.M. SantosI.P. de Oliveira Negrão RicardoL. LimaB.O. D’Orleans Farias MarinhoP. SoaresA.B. Silva Bastos AndradeL.O. Brasileiro PessoaS.M. Leles SilvaM.M. OliveiraM.C. Pinheiro da SilvaJ. MouraM.A. CruzM.P. MarquesL.M. SantosT.T. PiresP.N. Teixeira DiasJ.C. RezendeR.P. Trovatti UetanabaroA.P. YatsudaR. Antimicrobial activity of Lactobacillus fermentum TcUESC01 against Streptococcus mutans UA159.Microb. Pathog.202014210406310.1016/j.micpath.2020.10406332061821
     [Google Scholar]
  23. Homayouni RadA. PourjafarH. MirzakhaniE. A comprehensive review of the application of probiotics and postbiotics in oral health.Front. Cell. Infect. Microbiol.202313112099510.3389/fcimb.2023.112099536968114
     [Google Scholar]
  24. MahasnehS. MahasnehA. Probiotics: A Promising Role in Dental Health.Dent. J.2017542610.3390/dj504002629563432
     [Google Scholar]
  25. CannonM.L. VorachekA. LeC. WhiteK. Retrospective Review of Oral Probiotic Therapy.J. Clin. Pediatr. Dent.201943636737110.17796/1053‑4625‑43.6.131657987
     [Google Scholar]
  26. Di PierroF. ZanvitA. NobiliP. RissoP. FornainiC. Cariogram outcome after 90 days of oral treatment with Streptococcus salivarius M18 in children at high risk for dental caries: results of a randomized, controlled study.Clin. Cosmet. Investig. Dent.2015710711310.2147/CCIDE.S9306626491371
     [Google Scholar]
  27. ZhengH. XieT. LiS. QiaoX. LuY. FengY. Analysis of oral microbial dysbiosis associated with early childhood caries.BMC Oral Health202121118110.1186/s12903‑021‑01543‑x33827534
     [Google Scholar]
  28. Oral health surveys: basic methods - 5th edition.2013Available from: https://www.who.int/publications/i/item/9789241548649(accessed on 21-9-2024)
  29. IsmailA.I. PittsN.B. TellezM. BanerjeeA. DeeryC. DouglasG. EggertssonH. EkstrandK. EllwoodR. GomezJ. Jablonski-MomeniA. KolkerJ. LongbottomC. MantonD. MartignonS. McGradyM. RechmannP. RickettsD. SohnW. ThompsonV. TwetmanS. WeyantR. WolffM. ZandonaA. Authors of International Caries Classification and Management System (ICCMS) The International Caries Classification and Management System (ICCMS™) An Example of a Caries Management Pathway.BMC Oral Health201515S1Suppl. 1S910.1186/1472‑6831‑15‑S1‑S926391116
     [Google Scholar]
  30. Bárcena GarcíaM. Cobo PlanaJ.M. Rodríguez CagiaoG. Arcos GonzálezP.I. Epidemiological methods used in the periodontal health research in military personnel: a systematic review.BMJ Mil. Health20241701727710.1136/bmjmilitary‑2021‑00197734921095
     [Google Scholar]
  31. LuoT. SrinivasanU. RamaduguK. SheddenK.A. NeiswangerK. TrumbleE. LiJ.J. McNeilD.W. CroutR.J. WeyantR.J. MarazitaM.L. FoxmanB. Effects of Specimen Collection Methodologies and Storage Conditions on the Short-Term Stability of Oral Microbiome Taxonomy.Appl. Environ. Microbiol.201682185519552910.1128/AEM.01132‑1627371581
     [Google Scholar]
  32. ZauraE. PappalardoV.Y. BuijsM.J. VolgenantC.M.C. BrandtB.W. Optimizing the quality of clinical studies on oral microbiome: A practical guide for planning, performing, and reporting.Periodontol. 2000202185121023610.1111/prd.1235933226702
     [Google Scholar]
  33. XuL. WuZ. WangY. WangS. ShuC. DuanZ. DengS. High-throughput sequencing identifies salivary microbiota in Chinese caries-free preschool children with primary dentition.J. Zhejiang Univ. Sci. B202122428529410.1631/jzus.B200055433835762
     [Google Scholar]
  34. ChenW. JiangQ. YanG. YangD. The oral microbiome and salivary proteins influence caries in children aged 6 to 8 years.BMC Oral Health202020129510.1186/s12903‑020‑01262‑933115458
     [Google Scholar]
  35. YangF. ZengX. NingK. LiuK.L. LoC.C. WangW. ChenJ. WangD. HuangR. ChangX. ChainP.S. XieG. LingJ. XuJ. Saliva microbiomes distinguish caries-active from healthy human populations.ISME J.20126111010.1038/ismej.2011.7121716312
     [Google Scholar]
  36. ChenZ. RadjabzadehD. ChenL. KurilshikovA. KavousiM. AhmadizarF. IkramM.A. UitterlindenA.G. ZhernakovaA. FuJ. KraaijR. VoortmanT. Association of Insulin Resistance and Type 2 Diabetes With Gut Microbial Diversity.JAMA Netw. Open202147e211881110.1001/jamanetworkopen.2021.1881134323983
     [Google Scholar]
  37. LoT.T. Van LissaC.J. VerhagenM. HoemannK. ErbaşY. MaciejewskiD.F. A theory-informed emotion regulation variability index: Bray–Curtis dissimilarity.Emotion20242451273128510.1037/emo000134438358696
     [Google Scholar]
  38. Lif HolgersonP. ÖhmanC. RönnlundA. JohanssonI. Maturation of Oral Microbiota in Children with or without Dental Caries.PLoS One2015105e012853410.1371/journal.pone.012853426020247
     [Google Scholar]
  39. ParisottoT.M. Steiner-OliveiraC. SilvaC.M. RodriguesL.K. Nobre-dos-SantosM. Early childhood caries and mutans streptococci: a systematic review.Oral Health Prev. Dent.201081597020480056
     [Google Scholar]
  40. HughesC.V. DahlanM. PapadopolouE. LooC.Y. PradhanN.S. LuS.C. MathneyJ.M. BravocoA. KentR.L.Jr TannerA.C. Aciduric microbiota and mutans streptococci in severe and recurrent severe early childhood caries.Pediatr. Dent.2012342e16e2322583872
     [Google Scholar]
  41. TakahashiY. TakashimaE. ShimazuK. YagishitaH. AobaT. KonishiK. Contribution of sialic acid-binding adhesin to pathogenesis of experimental endocarditis caused by Streptococcus gordonii DL1.Infect. Immun.200674174074310.1128/IAI.74.1.740‑743.200616369032
     [Google Scholar]
  42. BelstrømD. FiehnN.E. NielsenC.H. HolmstrupP. KirkbyN. Klepac-CerajV. PasterB.J. TwetmanS. Altered bacterial profiles in saliva from adults with caries lesions: a case-cohort study.Caries Res.201448536837510.1159/00035750224643218
     [Google Scholar]
  43. XuL. ChenX. WangY. JiangW. WangS. LingZ. ChenH. Dynamic Alterations in Salivary Microbiota Related to Dental Caries and Age in Preschool Children With Deciduous Dentition: A 2-Year Follow-Up Study.Front. Physiol.2018934210.3389/fphys.2018.0034229670544
     [Google Scholar]
  44. JohanssonI. WitkowskaE. KavehB. Lif HolgersonP. TannerA.C.R. The Microbiome in Populations with a Low and High Prevalence of Caries.J. Dent. Res.2016951808610.1177/002203451560955426442950
     [Google Scholar]
  45. ParkerB.J. WearschP.A. VelooA.C.M. Rodriguez-PalaciosA. The Genus.Front. Immunol.20201190610.3389/fimmu.2020.0090632582143
     [Google Scholar]
  46. UlsemerP. ToutounianK. SchmidtJ. KarstenU. GoletzS. Preliminary safety evaluation of a new Bacteroides xylanisolvens isolate.Appl. Environ. Microbiol.201278252853510.1128/AEM.06641‑1122101046
     [Google Scholar]
  47. DurantiS. RuizL. LugliG.A. TamesH. MilaniC. MancabelliL. MancinoW. LonghiG. CarnevaliL. SgoifoA. MargollesA. VenturaM. Ruas-MadiedoP. TurroniF. Bifidobacterium adolescentis as a key member of the human gut microbiota in the production of GABA.Sci. Rep.20201011411210.1038/s41598‑020‑70986‑z32839473
     [Google Scholar]
  48. MalinenE. Krogius-KurikkaL. LyraA. NikkiläJ. JääskeläinenA. RinttiläT. Vilpponen-SalmelaT. von WrightA.J. PalvaA. Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome.World J. Gastroenterol.201016364532454010.3748/wjg.v16.i36.453220857523
     [Google Scholar]
  49. BelstrømD. HolmstrupP. FiehnN.E. KirkbyN. KokarasA. PasterB.J. BardowA. Salivary microbiota in individuals with different levels of caries experience.J. Oral Microbiol.201791127061410.1080/20002297.2016.127061428326153
     [Google Scholar]
  50. YousufB. MishraA. Exploring human bacterial diversity toward prevention of infectious disease and health promotion.Microbial Diversity in the Genomic Era. DasS. DashH.R. Academic Press201951953310.1016/B978‑0‑12‑814849‑5.00029‑0
     [Google Scholar]
  51. DeGruttolaA.K. LowD. MizoguchiA. MizoguchiE. Current understanding of dysbiosis in disease in human and animal models.Inflamm. Bowel Dis.20162251137115010.1097/MIB.000000000000075027070911
     [Google Scholar]
  52. FiorucciS. CarinoA. BaldoniM. SantucciL. CostanziE. GraziosiL. DistruttiE. BiagioliM. Bile Acid Signaling in Inflammatory Bowel Diseases.Dig. Dis. Sci.202166367469310.1007/s10620‑020‑06715‑333289902
     [Google Scholar]
  53. DewhirstF.E. ChenT. IzardJ. PasterB.J. TannerA.C.R. YuW.H. LakshmananA. WadeW.G. The human oral microbiome.J. Bacteriol.2010192195002501710.1128/JB.00542‑1020656903
     [Google Scholar]
  54. JiangS. GaoX. JinL. LoE. Salivary Microbiome Diversity in Caries-Free and Caries-Affected Children.Int. J. Mol. Sci.20161712197810.3390/ijms1712197827898021
     [Google Scholar]
  55. XiaoC. RanS. HuangZ. LiangJ. Bacterial Diversity and Community Structure of Supragingival Plaques in Adults with Dental Health or Caries Revealed by 16S Pyrosequencing.Front. Microbiol.20167114510.3389/fmicb.2016.0114527499752
     [Google Scholar]
  56. CostalongaM. HerzbergM.C. The oral microbiome and the immunobiology of periodontal disease and caries.Immunol. Lett.20141622223810.1016/j.imlet.2014.08.01725447398
     [Google Scholar]
  57. AgnelloM. MarquesJ. CenL. MittermullerB. HuangA. Chaichanasakul TranN. ShiW. HeX. SchrothR.J. Microbiome Associated with Severe Caries in Canadian First Nations Children.J. Dent. Res.201796121378138510.1177/002203451771881928709393
     [Google Scholar]
  58. CrielaardW. ZauraE. SchullerA.A. HuseS.M. MontijnR.C. KeijserB.J.F. Exploring the oral microbiota of children at various developmental stages of their dentition in the relation to their oral health.BMC Med. Genomics2011412210.1186/1755‑8794‑4‑2221371338
     [Google Scholar]
  59. LiuG. WuC. AbramsW.R. LiY. Structural and Functional Characteristics of the Microbiome in Deep-Dentin Caries.J. Dent. Res.202099671372010.1177/002203452091324832196394
     [Google Scholar]
  60. HurleyE. BarrettM.P.J. KinironsM. WheltonH. RyanC.A. StantonC. HarrisH.M.B. O’TooleP.W. Comparison of the salivary and dentinal microbiome of children with severe-early childhood caries to the salivary microbiome of caries-free children.BMC Oral Health20191911310.1186/s12903‑018‑0693‑130642327
     [Google Scholar]
  61. BeckerM.R. PasterB.J. LeysE.J. MoeschbergerM.L. KenyonS.G. GalvinJ.L. BochesS.K. DewhirstF.E. GriffenA.L. Molecular analysis of bacterial species associated with childhood caries.J. Clin. Microbiol.20024031001100910.1128/JCM.40.3.1001‑1009.200211880430
     [Google Scholar]
  62. GrossE.L. LeysE.J. GasparovichS.R. FirestoneN.D. SchwartzbaumJ.A. JaniesD.A. AsnaniK. GriffenA.L. Bacterial 16S sequence analysis of severe caries in young permanent teeth.J. Clin. Microbiol.201048114121412810.1128/JCM.01232‑1020826648
     [Google Scholar]
  63. GoretJ. BaudinetT. CamouF. IssaN. GaillardP. WirthG. GreibC. BarandonL. MégraudF. BébéarC. PeuchantO. MénardA. Identification of Streptococcus sinensis from a patient with endocarditis using MALDI-TOF mass spectrometry, 16S rDNA- and sodA-based phylogeny.J. Microbiol. Immunol. Infect.201952350750910.1016/j.jmii.2018.04.00429891358
     [Google Scholar]
  64. SpataforaG. LiY. HeX. CowanA. TannerA.C.R. The Evolving Microbiome of Dental Caries.Microorganisms202412112110.3390/microorganisms1201012138257948
     [Google Scholar]
  65. MeriçE. BolgülB. DuranN. AyE. Evaluation of oral streptococci in saliva of children with severe Early Childhood Caries and caries-free.Eur. J. Paediatr. Dent.2020211131710.23804/ejpd.2020.21.01.0332183522
     [Google Scholar]
  66. AndersonA.C. RothballerM. AltenburgerM.J. WoelberJ.P. KarygianniL. LagkouvardosI. HellwigE. Al-AhmadA. In-vivo shift of the microbiota in oral biofilm in response to frequent sucrose consumption.Sci. Rep.2018811420210.1038/s41598‑018‑32544‑630242260
     [Google Scholar]
  67. MartínV. Mañes-LázaroR. RodríguezJ.M. Maldonado-BarragánA. Streptococcus lactarius sp. nov., isolated from breast milk of healthy women.Int. J. Syst. Evol. Microbiol.20116151048105210.1099/ijs.0.021642‑020511454
     [Google Scholar]
  68. TapiainenT. PaalanneN. ArkkolaT. RenkoM. PokkaT. KaijalainenT. UhariM. Diet as a risk factor for pneumococcal carriage and otitis media: a cross-sectional study among children in day care centers.PLoS One201493e9058510.1371/journal.pone.009058524599395
     [Google Scholar]
  69. KistlerJ.O. BoothV. BradshawD.J. WadeW.G. Bacterial community development in experimental gingivitis.PLoS One201388e7122710.1371/journal.pone.007122723967169
     [Google Scholar]
  70. WangY. ZhangJ. ChenX. JiangW. WangS. XuL. TuY. ZhengP. WangY. LinX. ChenH. Profiling of oral microbiota in early childhood caries using single-molecule real-time sequencing.Front. Microbiol.20178224410.3389/fmicb.2017.0224429187843
     [Google Scholar]
  71. RawlinsonA. DuerdenB.I. GoodwinL. New findings on the microbial flora associated with adult periodontitis.J. Dent.199321317918410.1016/0300‑5712(93)90029‑P8315093
     [Google Scholar]
  72. LoozenG. BoonN. PauwelsM. SlomkaV. Rodrigues HerreroE. QuirynenM. TeughelsW. Effect of Bdellovibrio bacteriovorus HD100 on multispecies oral communities.Anaerobe201535Pt A455310.1016/j.anaerobe.2014.09.01125252124
     [Google Scholar]
  73. Seminario-AmezM. López-LópezJ. Estrugo-DevesaA. Ayuso-MonteroR. Jané-SalasE. Probiotics and oral health: A systematic review.Med. Oral Patol. Oral Cir. Bucal2017223010.4317/medoral.2149428390121
     [Google Scholar]
  74. PfaffeT. Cooper-WhiteJ. BeyerleinP. KostnerK. PunyadeeraC. Diagnostic potential of saliva: current state and future applications.Clin. Chem.201157567568710.1373/clinchem.2010.15376721383043
     [Google Scholar]
  75. YangY. WengW. PengJ. HongL. YangL. ToiyamaY. GaoR. LiuM. YinM. PanC. LiH. GuoB. ZhuQ. WeiQ. MoyerM.P. WangP. CaiS. GoelA. QinH. MaY. Fusobacterium nucleatum increases proliferation of colorectal cancer cells and tumor development in mice by activating toll-like receptor 4 signaling to nuclear factor−κb, and up-regulating expression of microRNA-21.Gastroenterology20171524851866.e2410.1053/j.gastro.2016.11.01827876571
     [Google Scholar]
  76. KimM. FriesenL. ParkJ. KimH.M. KimC.H. Microbial metabolites, short-chain fatty acids, restrain tissue bacterial load, chronic inflammation, and associated cancer in the colon of mice.Eur. J. Immunol.20184871235124710.1002/eji.20174712229644622
     [Google Scholar]
/content/journals/raiad/10.2174/0127722708335159241117062704
Loading
Analysis of Oral and Gut Microbiota Composition in Children with Dental Caries by NGS Approaches
Rec Adv Inflamm Allergy Drug Discov 19, 413 (2025); https://doi.org/10.2174/0127722708335159241117062704
/content/journals/raiad/10.2174/0127722708335159241117062704
/content/journals/raiad/10.2174/0127722708335159241117062704
Loading

Data & Media loading...

Supplements

Supplementary material is available on the publisher's website along with the published article.

file format download Download

  • Article Type:     Research Article
Keyword(s): microbial ecology; molecular biology; next generation sequencing; oral health; Paediatric dentistry; probiotics

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test