Roles of Nitric Oxide Synthase inhibitor on Antinociceptive Effects of μ-Opioid Agonist in Mice

Li-Xiang Chen; Yuan-Ming Qi; Rui Wang; Xin Duan; Yan-Feng Gao; Ding-Jian Yang

doi:10.2174/092986606778777443

ISSN: 0929-8665
E-ISSN: 1875-5305

Roles of Nitric Oxide Synthase inhibitor on Antinociceptive Effects of μ-Opioid Agonist in Mice
Authors: Li-Xiang Chen¹, Yuan-Ming Qi², Rui Wang³, Xin Duan⁴, Yan-Feng Gao⁵ and Ding-Jian Yang⁶
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¹ Department of Bioengineering,Zhengzhou University, 100 Science Road, Zhengzhou, 450001, P. R.China. ² Department of Bioengineering,Zhengzhou University, 100 Science Road, Zhengzhou, 450001, P. R.China. ³ Department of Bioengineering,Zhengzhou University, 100 Science Road, Zhengzhou, 450001, P. R.China. ⁴ Department of Bioengineering,Zhengzhou University, 100 Science Road, Zhengzhou, 450001, P. R.China. ⁵ Department of Bioengineering,Zhengzhou University, 100 Science Road, Zhengzhou, 450001, P. R.China. ⁶ Department of Bioengineering,Zhengzhou University, 100 Science Road, Zhengzhou, 450001, P. R.China.
Source: Protein and Peptide Letters, Volume 13, Issue 10, Oct 2006, p. 993 - 997
DOI: https://doi.org/10.2174/092986606778777443
- Available online: 01 Oct 2006

Abstract

In the present study, it was found that intraperitoneal (i.p.) pre-injection of NG-nitro-L-arginine methyl ester (LNAME) significantly influenced the endomorphin-1 (EM-1) and endomorphin-2 (EM-2) induced antinociception. These effects could be inhibited or reversed by L-Arg or naloxone. Our results suggest that the modulatory effect of NO system on the mu-receptor evoked analgesia is different between the two mu receptor subtypes.

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2006-10-01

2025-06-17

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Article Type: Research Article

Keyword(s): Analgesia; Endomorphin; L-arginine; Mice; NG-nitro-L-arginine methyl ester; Nitric oxide

Roles of Nitric Oxide Synthase inhibitor on Antinociceptive Effects of μ-Opioid Agonist in Mice

Abstract

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