Pharmaceutical Nanotechnology - Volume 5, Issue 3, 2017

Background: C60-fullerenes (CFs) constitute a carbon-allotropic family with cage-like fused-ring structure, comprising of 20 hexagons and 12 pentagons. Since discovery in 1985, CFs attracted the scientists from various strata for unique properties like tensile strength, nanometeric size, symmetric nature, thermal and photo conductivity, chemical tailoring opportunities and drug loading capabilities. Surprisingly, CFs are al Read More

Background: Nanomedicine is a branch which deals with medicinal products, devices, nonbiological complex drugs and antibody-nanoparticle conjugates and general health products that are manufactured using nanotechnology. Objective: Nano-medicine provides the same efficacies as traditional medicines owing to their improved solubility and bioavailability with reduced dosages. However, there are currently safety co Read More

Background: Nifedipine is a potential therapeutic agent for the treatment of cardiovascular disturbances, although it suffers from short half-life (t1/2, 2 hr). Objective: To address the problem, we first prepared nifedipine loaded sustained release microsponges and then formulated tablets for effective clinical application and patient compliance. Method: Preparations of microsponges were carried out using different composition Read More

Background: The convoluted pathophysiology of brain disorders along with penetration issue of drugs to brain represents major hurdle that requires some novel therapies. The blood-brain barrier (BBB) denotes a rigid barrier for delivery of therapeutics in vivo; to overcome this barrier, intranasal delivery is an excellent strategy to deliver the drug directly to brain via olfactory and trigeminal nerve pathways that originate Read More

Background: Conventional nanofiber forming peptide amphiphiles comprise a beta sheet forming, short peptide sequence with an alkyl chain attached at one terminus. We report the selfassembly of a peptide amphiphile possessing a mid-chain located alkyl substituent (a T-shaped peptide amphiphile) into nanofiber networks. Method: Peptide synthesis was carried out using standard 9-fluorenylmethoxycarbonyl solid phase Read More

Background: Along with the intensified use of metal nanoparticles, growing concern of their adverse outcome on human health has also expanded, indicating that this work is an integral part of nanobioscience study. Objective: The aim of this study was to evaluate varied effect of biosynthesized gold nanoparticles (AuNPs) on normal and cancerous mammalian cells. Methods: AuNP synthesized and characterized by different chara Read More

Background: Chitosan nanoparticle, a potential vehicle, is used as a hydrophilic carrier system since it can deliver drugs to specific sites and also control the drug release rate. Moreover, controlled release systems are designed to minimize systemic absorption and to achieve optimum delivery of the biologically active mesalamine to the distal small intestine and the colon. Objective: The current study investigated the developme Read More