Mini-Reviews in Organic Chemistry - Volume 8, Issue 1, 2011

Supramolecular chemistry---the branch of chemistry involved with the control of intermolecular interactions to produce valuable new devices and molecular assemblies--- has been a major research theme for the past four decades. Especially, anionic species based supramolecular chemistry, including recognition and sensing of anions, has emerged rapid growth recently. Arising from the important roles the anionic species pla Read More

A new chromogenic sensor, 1,10-phenanthroline affixed to the 2,4-dinitrophenylhydrazine moiety, was synthesized and characterized. Among anions added into it, F-, AcO- and H2PO4- ions resulted in the color changes from light brown to dark brown, while other tested anions did not induce color changes. Meanwhile, the anion-binding ability has been investigated by UV-vis and 1H NMR titrations in DMSO-d6. The sens Read More

Two bis urea based acyclic receptors (1 and 2) containing two pyridyl moieties with different spacers are synthesized. These receptors are further transformed to metallo-macrocyclic receptors (3 and 4) by coordinating with metal center through pyridine ring ‘N’. The binding-behavior as well as selectivity of the receptors towards anions upon metal coordinated cyclization is studied and the results are compared with parent acycli Read More

Indole-based anion receptors are developing rapidly nowadays due to a nearly limitless derivatizing capability of indole functionality. This mini-review summarizes the progress on synthetic anion receptors containing indole functionality from 2008 to date, including the recognition behaviors and sensing properties of these receptors for different anions.

A simple and novel receptor 1 based on indole-3-aldehyde and 2, 4-diphenylhydrazine is synthesized by a simple way, which displays good selectively and sensitivity for detection of acetate, fluoride and dihydregen phosphate anion in dry DMSO and in DMSO/H2O (95/5) solutions. Combining with the anions induces the visible color changes that the naked-eye detection maybe realized. Meanwhile, the binding prope Read More

A new benzimidazolium - based chiral fluororeceptor 1 has been designed and synthesized. The open cleft of 1 is found to recognize fumarate selectively over maleate in CH3CN by exhibiting greater change in emission. In comparison, the achiral receptor 2, under similar condition, shows poor selectivity in the recognition of fumarate over maleate. Interaction studies were performed by 1H NMR, fluorescence and UV-vis sp Read More

Among the synthetic vectors exploitable in Human Gene Therapy (HGT), complexes of DNA with cationic liposomes (lipoplexes) are considered the best candidates. Some degree of cytotoxicity and a limited stability on serum are still limiting factors for applications in vivo. On the contrary the corresponding complexes of neutral liposomes are enough stable and non toxic. This review has the aim to offer a survey of existing dat Read More

A review on the tandem [4+2]/[3+2] cycloaddition reactions of 1,3,4-oxadiazoles with alkenes is presented. This reaction presents a powerful synthetic tool in the construction of complex polycyclic molecules in a one-pot reaction. Special attention is paid to synthesis of [n]polynorbornane and oxanorbornyl systems. In continuation, a review on the 1,3,4-oxadiazole reactions used in stereoselective total synthesis of alkaloids Read More

This review will focus on the recent applications of chiral Schiff base in asymmetric catalysis. The developments in the preparation and use of chiral Schiff base in a variety of asymmetric transformations will be covered. Some remarkable characteristics and catalytic mechanisms of these reactions will be mentioned and the limitations of some asymmetric reactions will be also discussed.

Silica sulfuric acid (SSA) has been used as an efficient solid acidic catalyst for many organic reactions. In this review, we wish to report some applications of this catalyst in organic synthesis.

Benzoxathiolones and its derivatives are important pharmacophores with diversified pharmacological activities like antibacterial, antimycotic, antioxidant and anti-inflammatory. These different biological applications for benzoxathiolone compounds have motivated new studies in searching novel derivatives with better activity results and also other applications in pharmaceutical industry. Owing to the importance of this syste Read More