Mini-Reviews in Organic Chemistry - Volume 19, Issue 1, 2022

The genus Flindersia comprises 17 species distributed in Australia, New Caledonia, New Guinea, and the Maluku Islands. With a variety of classes of secondary metabolites, including terpenes, alkaloids, lignans, flavonoids, coumarins, among other compounds, to date, the genus has not been widely studied phytochemically, having more value in the timber industry. However, the objective of this review is to gather the necessar Read More

Diabetes mellitus refers to one of the leading cause of diseases that affect large populations of human and is characterized by a high glucose level in the blood (also known as hyperglycemia). Thiazolidinedione (TZD) is a five-member heterocyclic compound consisting of three carbons, nitrogen and sulfur. It is also known as glitazones, can be used as potent hypoglycemic agents and is also reduce many other cardiovascular risk Read More

Recent studies have shown that one-pot synthesis is a boon for triazines synthesis. One-pot processes had significant success in carrying out complex reactions under mild and eco-friendly conditions. One-pot synthesis is environmentally benign and more economical than other processes of triazine synthesis. The triazine scaffold has provided the starting key point for the design and development of pharmaceutical molecul Read More

The marine sponges of the genus Oceanapia sp. is comprised of more than 50 species and are distributed in the seas around the tropical and subtropical regions. They are mainly found in the northern Indian oceans, Japan, and the south pacific coast. They are highly colored and known to be a rich source of various secondary metabolites, particularly alkaloids. Several other secondary metabolites are also reported from thi Read More

This review describes the synthesis and chemical reactivity of tetrahydrothieno[3,2-b] quinoline derivatives through many reagents such as; 1, 2-dihydropyridine-3-carbonitrile; 1,6-dihydropyrimidine- 5-carbonitrile; 2,3-dihydropyridazine-4-carbonitrile; 3-amino-thiophene-2-carboxylate; 3- amino-thiophene-2-carbonitrile; 3,4-diaminothieno[2,3-b] thiophene-2,5-dicarbo- nitrile; 2-(3-bromo-1- iodoisoquinolin-8-yl) benzonitrile Read More

Catalysts contribute significantly to the industrial revolution in terms of reaction rates and reduction in production costs. Extensive research has been documented on various industrial catalysis in the last few decades. The performance of catalysts is influenced by many parameters, including synthesis methods. The current work overviews the most common methods applied for the synthesis of supported catalysts. This review Read More

Hydroxychloroquine (HCQ) is an extremely important drug used for the treatment of various ailments. WHO listed it as one of the essential drugs. The utility of hydroxychloroquine (HCQ) as prophylaxis of COVID19, although debated, is well known. We have reviewed synthetic strategies for the industrial and academic synthesis of HCQ and its key intermediates like 4,7-dichloroquinoline (4,7- DCQ) and 2-((4-aminopentyl)(ethyl)a Read More

The review discusses different methods for the preparation of 2,6-diphenyl-piperidin-4-one derivatives. 2,6-Diphenyl-piperidin-4-one is prepared from aromatic aldehyde and acetone in ammonium acetate. Reaction of 1-phenylsulfinylpropan-2-one or 1-(4-chlorophenylsulfinyl)propan-2-one, aromatic aldehyde and ammonium acetate gives a series of 2,6-diaryl-2,3-dihydro-1H-pyridin-4-one 6a,b. 4-Phenyl-2-amino-1,3-butadie Read More