Mini-Reviews in Organic Chemistry - Volume 11, Issue 1, 2014

Infectious diseases are a significant cause of morbidity and mortality worldwide, accounting for approximately 50% of all deaths in tropical countries and as much as 20% of deaths in the USA. The emergence of multi-drug resistant (MDR) strains makes the risk of these infections even more threatening and an important public health problem thereby increasing need of new agents for fighting pathogens. In this review, Read More

The extensive use of antibiotics in medicine, food industry, and agriculture has led to a frequent emergence of multidrug-resistant bacteria, which creates an urgent need for new antibiotics. It is now widely recognized that venom proteins could play a promising role against multidrug-resistant bacteria. Different proteins with antibacterial activity have been characterized from the venoms of snakes, spiders and scorpions in the l Read More

Snake venoms are rich sources of metalloproteinases that are of biological interest due to their diverse molecular diversity and selective therapeutic applications. Snake venoms metalloproteinases (SVMPs) belong to the MEROPS peptidase family M12B or reprolysin subfamily, which are consisted of four major domains include a reprolysin catalytic domain, a disintegrin domain, a reprolysin family propeptide domain a Read More

It is a time tested phenomenon that in spite of deadly toxins in snake venoms, they are used for curing certain ailments of human suffering. Historically this application appears to co-evolve in many countries where India has significant contribution. Before independence, few British surgeons and naturalists documented the profile of snakes in India and investigated their venoms. With the advancement of technology, Read More

The use of microwave energy in chemical reactions has revolutionized the field of heterocyclic chemistry in the past two decades. Synergy of microwave methodology with reactions performed on support media and/or in the absence of solvent constitutes an environmentally clean technique, that offers tremendous advantages such as clean chemistry, reduction in reaction times, improved yields, and applicability to Read More

Spirocyclic scaffolds are embedded in many biologically active natural and synthetic compounds. Efforts have been made time to time to develop new and better methodologies for the preparation of spirocyclic compounds. Noteworthy advantages were observed during the course of our study on “in water” synthesis of spirocyclic compounds. The established advantages of using water as a solvent in reactions are: water is the Read More

Catalytic asymmetric oxidation of prochiral sulfides has been a challenging goal for years, which reflects the importance of sulfinyl group as a chiral controller in many organic transformations, as well as the existence of natural and synthetic biologically active products that need a sulfinyl group with a defined stereoconfiguration. 30 years ago, owing to the milestone discoveries of Kagan and Modena, titanium-dialkyltartrate/alkyl Read More

The reflection of green chemistry for the synthesis of a wide range of compounds via multi-component reaction systems is discussed in this paper. It also describes the most interesting, atom-economic Mannich and Mannich type reactions, their processes via green methods, solvents, green solvents, solvent effects, catalysts, catalyst effects, selectivity, kinetics, etc. They are indeed environmentally and ecologically benign.