Green is the New Black: Emerging Environmentally Friendly Prospects in the Synthesis of Quinoxaline Derivatives

Functionalized polysubstituted quinoxalines have been widely reported to possess appealing biological activities of great pharmaceutical importance, which drew researchers into exploring promising synthetic protocols. On top of that, prospects on green chemistry are driving research paradigms into more cost-effective, facile, environmental-friendly, sustainable, and scalable approaches. This paper reviews the green synthesis methods of quinoxaline derivatives using recyclable heterogeneous catalysts, green solvents and energy-mediated methods that have been extensively studied and published since 2010 to offer an insight into the ongoing greener trend in the scientific field.